HGNC ID: 8005
Target Abstract:
Neurociliin-2 (NRP2) is encoded in humans by the NRP2 gene, and the encoding product is a member of the neurociliin family of receptor proteins. The transmembrane protein binds to SEMA3C and SEMA3F proteins and interacts with vascular growth factor (VEGF). NRP2 plays a role in cardiovascular development, axonal guidance and tumorigenesis. There are also multiple transcript variants of this gene, encoding different subtypes.
NRP2 Target Infomation Overview
- Target Symbol: NRP2, neuropilin 2
- Alias: VEGF165R2
NRP2, neuropilin 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human NRP2 Target Information
- Target Symbol: NRP2, neuropilin 2
- Alias:
- MGC126574
- neuropilin-2
- neuropilin-2a(17)
- neuropilin-2a(22)
- neuropilin-2b(0)
- NP2
- NPN2
- PRO2714
- receptor for VEGF165 and semaphorins class3
- vascular endothelial cell growth factor 165 receptor 2
- vascular endothelial growth factor-165 receptor 2
- VEGF165R2
- NCBI_Gene: 8828
- UniProtKB: O60462
Human NRP2 Predicted Functions
Enables identical protein binding activity. Predicted to be involved in nervous system development and outflow tract septum morphogenesis. Predicted to act upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitory factor; and neural crest cell migration. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse. Predicted to be integral component of postsynaptic membrane.
Mouse Nrp2 Target Information
- Target Symbol: Nrp2, neuropilin 2
- Alias:
- 1110048P06Rik
- NP-2
- NP2
- Npn-2
- Npn2
- RIKEN cDNA 1110048P06 gene
- NCBI_Gene: 18187
Mouse Nrp2 Predicted Functions
Enables semaphorin receptor activity. Involved in several processes, including nervous system development; outflow tract septum morphogenesis; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitory factor; and neural crest cell migration. Located in axon. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and limb. Used to study autism spectrum disorder. Orthologous to human NRP2 (neuropilin 2).
Rat Nrp2 Target Information
- Target Symbol: Nrp2, neuropilin 2
- Alias:
- neuropilin-2
- vascular endothelial cell growth factor 165 receptor 2
- NCBI_Gene: 81527
- UniProtKB: O35276
Rat Nrp2 Predicted Functions
Predicted to enable identical protein binding activity and semaphorin receptor activity. Involved in axon guidance. Predicted to be located in axon. Predicted to be active in glutamatergic synapse. Predicted to be integral component of postsynaptic membrane. Orthologous to human NRP2 (neuropilin 2).
