HGNC ID: 7067
Target Abstract:
The full name of MHC is major histocompatibility complex, a group of genes that determines the compatibility of transplanted tissues and is closely related and tightly interlocked with the immune response, and is found only in antigen-presenting cells and lymphocytes.The MHC Class II contains two chains, the α and β chains, each of which contains two regions, the α chain contains the α1 and α2 regions, and the β chain contains the β1 and β2 regions, and the α2 and β2 are the transmembrane structural domains that anchor MHC Class II molecules to the cell membrane. The peptide binding site is found between the heterodimers formed by α1 and β1.
CIITA Target Infomation Overview
- Target Symbol: CIITA, class II major histocompatibility complex transactivator
- Gene Groups: NLR family
- Alias: C2TA; NLRA
- Previous Names: MHC2TA
- Alias Names: NLR family, acid domain containing; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing; MHC class II transactivator; class II, major histocompatibility complex, transactivator
CIITA, class II major histocompatibility complex transactivator Target Infomation by Species
- Human
- Mouse
- Rat
Human CIITA Target Information
- Target Symbol: CIITA, class II major histocompatibility complex transactivator
- Alias:
- C2TA
- CIITAIV
- class II, major histocompatibility complex, transactivator
- MHC class II transactivator
- MHC class II transactivator type I
- MHC class II transactivator type III
- MHC2TA
- NLR family, acid domain containing
- NLRA
- nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
- NCBI_Gene: 4261
- UniProtKB: P33076
Human CIITA Predicted Functions
Enables DNA-binding transcription factor binding activity; protein C-terminus binding activity; and transcription cis-regulatory region binding activity. Involved in negative regulation of viral entry into host cell; regulation of macromolecule biosynthetic process; and response to interferon-gamma. Acts upstream of or within response to antibiotic. Located in PML body and cytosol. Implicated in Addison’s disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction.
Mouse Ciita Target Information
- Target Symbol: Ciita, class II transactivator
- Alias:
- C2ta
- EG669998
- Gm9475
- predicted gene 9475
- predicted gene, EG669998
- NCBI_Gene: 12265
Mouse Ciita Predicted Functions
Predicted to enable DNA-binding transcription factor binding activity; protein C-terminus binding activity; and transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II and response to interferon-gamma. Acts upstream of or within negative regulation of transcription, DNA-templated. Predicted to be located in PML body; cell surface; and cytosol. Is expressed in bladder; central nervous system; and retina. Used to study MHC class II deficiency and osteoporosis. Human ortholog(s) of this gene implicated in Addison’s disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction. Orthologous to human CIITA (class II major histocompatibility complex transactivator).
Rat Ciita Target Information
- Target Symbol: Ciita, class II, major histocompatibility complex, transactivator
- Alias:
- C2ta
- class II transactivator
- MHC class II transactivator
- MHC class II transactivator type IV
- Mhc2ta
- NCBI_Gene: 85483
Rat Ciita Predicted Functions
Predicted to enable DNA-binding transcription factor binding activity; protein C-terminus binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to electrical stimulus; cellular response to exogenous dsRNA; and regulation of macromolecule biosynthetic process. Located in cell surface. Used to study periapical periodontitis. Human ortholog(s) of this gene implicated in Addison’s disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction. Orthologous to human CIITA (class II major histocompatibility complex transactivator).