HGNC ID: 11821
Target Abstract:
Tissue metalloproteinase inhibitor 2 (TIMP2) gene is a member of the TIMP gene family. Of the four known members of the TIMP family, TIMP-2 has both features common to all TIMPs and its own unique features. The proteins encoded by this gene family are natural inhibitors of matrix metalloproteinases (MMP), a group of peptidases involved in the degradation of extracellular matrix. TIMP2 acts as both an MMP inhibitor and an activator. TIMP-1 inhibited the activity of MMP-7, MMP-9, MMP-1 and MMP-3 better than TIMP-2, while TIMP-2 inhibited the activity of MMP-2 more effectively than other TIMPs. In melanocytes, the expression of TIMP2 gene may be regulated by MITF. Recent studies have found that TIMP2 plays an important role in hippocampal function and cognitive function.
TIMP2 Target Infomation Overview
- Target Symbol: TIMP2, TIMP metallopeptidase inhibitor 2
- Gene Groups: Tissue inhibitor of metallopeptidases
- Alias: CSC-21K
- Alias Names: tissue inhibitor of metalloproteinase 2
TIMP2, TIMP metallopeptidase inhibitor 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human TIMP2 Target Information
- Target Symbol: TIMP2, TIMP metallopeptidase inhibitor 2
- Alias:
- CSC-21K
- DDC8
- KIAA1731NL
- metalloproteinase inhibitor 2
- testicular secretory protein Li 57
- TIMP-2
- tissue inhibitor of metalloproteinase 2
- tissue inhibitor of metalloproteinases 2
- NCBI_Gene: 7077
- UniProtKB: P16035
Human TIMP2 Predicted Functions
Enables peptidase inhibitor activity; protease binding activity; and zinc ion binding activity. Involved in negative regulation of metallopeptidase activity. Located in collagen-containing extracellular matrix. Implicated in Moyamoya disease. Biomarker of several diseases, including Duchenne muscular dystrophy; aortic disease (multiple); carcinoma (multiple); neurodegenerative disease (multiple); and preretinal fibrosis.
Mouse Timp2 Target Information
- Target Symbol: Timp2, tissue inhibitor of metalloproteinase 2
- Alias:
- D11Bwg1104e
- DNA segment, Chr 11, Brigham & Women’s Genetics 1104 expressed
- Timp-2
- TIMP-2
- NCBI_Gene: 21858
Mouse Timp2 Predicted Functions
Enables enzyme activator activity; integrin binding activity; and metalloendopeptidase inhibitor activity. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Located in basement membrane and cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and skeletal system. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2).
Rat Timp2 Target Information
- Target Symbol: Timp2, TIMP metallopeptidase inhibitor 2
- Alias:
- metalloproteinase inhibitor 2
- MGC105282
- TIMP-2
- tissue inhibitor of metalloproteinase 2
- tissue inhibitor of metalloproteinases 2
- NCBI_Gene: 29543
- UniProtKB: P30121
Rat Timp2 Predicted Functions
Enables integrin binding activity and metalloendopeptidase inhibitor activity. Involved in several processes, including positive regulation of adenylate cyclase activity; positive regulation of neuron differentiation; and regulation of intracellular signal transduction. Located in several cellular components, including cell surface; growth cone; and neuronal cell body. Used to study portal hypertension. Biomarker of cardiomyopathy; congestive heart failure; and intracranial aneurysm. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2).
