HGNC ID: 6563
Target Abstract:
Galactose lectin-3 (Galectin-3) belongs to the lectin family and is expressed in the nucleus, cytoplasm, mitochondria, cell surface, and extracellularly.Galectin-3 has an affinity for β-galactosidase and exhibits anti-bacterial and antifungal activity. It is involved in many biological processes such as cell adhesion, cell activation and chemotaxis, cell growth and differentiation, cell cycle, and apoptosis. Based on its wide range of biological functions, Galectin-3 is thought to be associated with cancer, inflammation and fibrosis, heart disease, stroke, etc. Galectin-3 expression levels have been correlated with various types of fibrosis. Galectin-3 expression is upregulated in liver fibrosis, renal fibrosis, and idiopathic pulmonary fibrosis (IPF). In acute decompensated heart failure and chronic heart failure populations, high expression of Galectin-3 resulted in a higher risk of death. Meanwhile, Galectin-3 is thought to have an important role in tumor metastasis.
LGALS3 Target Infomation Overview
- Target Symbol: LGALS3, galectin 3
- Gene Groups: Receptor ligands; Galectins
- Alias: MAC-2; GALIG
- Previous Names: LGALS2
- Alias Names: advanced glycation end-product receptor 3; lectin, galactoside-binding, soluble, 3
LGALS3, galectin 3 Target Infomation by Species
- Human
- Mouse
- Rat
Human LGALS3 Target Information
- Target Symbol: LGALS3, galectin 3
- Alias:
- 35 kDa lectin
- advanced glycation end-product receptor 3
- carbohydrate-binding protein 35
- CBP35
- GAL3
- galactose-specific lectin 3
- GALBP
- galectin-3
- GALIG
- IgE-binding protein
- L31
- laminin-binding protein
- lectin L-29
- lectin, galactose binding, soluble 3
- lectin, galactoside binding soluble 3
- lectin, galactoside-binding, soluble, 3
- LGALS2
- MAC-2 antigen
- MAC2
- NCBI_Gene: 3958
- UniProtKB: P17931
Human LGALS3 Predicted Functions
Enables several functions, including IgE binding activity; chemoattractant activity; and laminin binding activity. Involved in several processes, including leukocyte chemotaxis; positive regulation of protein localization to plasma membrane; and regulation of apoptotic process. Located in immunological synapse; mitochondrial inner membrane; and nucleus. Is active in extracellular space. Colocalizes with collagen-containing extracellular matrix. Implicated in asthma. Biomarker of aortic valve stenosis and liver cirrhosis.
Mouse Lgals3 Target Information
- Target Symbol: Lgals3, lectin, galactose binding, soluble 3
- Alias:
- gal3
- galectin-3
- L-34
- Mac-2
- NCBI_Gene: 16854
Mouse Lgals3 Predicted Functions
Predicted to enable several functions, including IgE binding activity; advanced glycation end-product receptor activity; and signaling receptor binding activity. Involved in negative regulation of T cell receptor signaling pathway; negative regulation of endocytosis; and negative regulation of lymphocyte activation. Acts upstream of or within extracellular matrix organization and skeletal system development. Located in several cellular components, including external side of plasma membrane; glial cell projection; and immunological synapse. Is expressed in several structures, including alimentary system; genitourinary system; respiratory system; skeleton; and skin. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3).
Rat Lgals3 Target Information
- Target Symbol: Lgals3, galectin 3
- Alias:
- 35 kDa lectin
- AGE-R3
- carbohydrate-binding protein 35
- CBP 35
- CBP30
- epsilon BP
- gal-3
- galactose-specific lectin 3
- galectin-3
- IgE binding protein
- L-34
- laminin-binding protein
- lectin galactoside-binding soluble 3 protein
- lectin L-29
- lectin, galactose binding, soluble 3
- lectin, galactoside-binding, soluble, 3
- mac-2 antigen
- MGC105387
- NCBI_Gene: 83781
Rat Lgals3 Predicted Functions
Enables several functions, including Fc-gamma receptor I complex binding activity; IgE binding activity; and advanced glycation end-product receptor activity. Involved in several processes, including negative regulation of cell proliferation in bone marrow; positive regulation of angiogenesis; and positive regulation of serotonin secretion. Located in several cellular components, including cell surface; extracellular space; and nucleus. Biomarker of several diseases, including acute kidney failure; attention deficit hyperactivity disorder; brain ischemia; congestive heart failure; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3).
