HGNC ID: 4883
Target Abstract:
Complement factor H, also known as factor H1 and CFH, is a sialic acid-containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system, which is involved in microbial defense, immune complex processing, and programmed cell death.CFH acts as a regulator of the alternative pathways of the complement system by ensuring that the associated immune response acts on foreign pathogens that are not host cells. CFH protects self-cells from complement activation, but not bacteria and viruses.Misregulation of CFH may adversely affect the ability to deal with foreign infections or to reduce host cell complement activity.Mutations in the factor H gene have been associated with a variety of serious diseases, including the rare kidney disorders hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN), also known as dense matter deposition disease ( DDD), type II membranoproliferative glomerulonephritis or dense deposit disease, and the more common age-related macular degeneration (AMD).
CFH Target Infomation Overview
- Target Symbol: CFH, complement factor H
- Gene Groups: Sushi domain containing; Complement system regulators and receptors
- Alias: HUS; FHL1; ARMS1; ARMD4
- Previous Names: HF; HF1; HF2
- Alias Names: beta-1H; H factor 2 (complement); age-related maculopathy susceptibility 1; H factor 1 (complement)
CFH, complement factor H Target Infomation by Species
- Human
- Mouse
- Rat
Human CFH Target Information
- Target Symbol: CFH, complement factor H
- Alias:
- adrenomedullin binding protein
- age-related maculopathy susceptibility 1
- AHUS1
- AMBP1
- ARMD4
- ARMS1
- beta-1-H-globulin
- beta-1H
- CFHL3
- complement factor H, isoform b
- factor H
- factor H-like 1
- FH
- FHL1
- H factor 1 (complement)
- H factor 2 (complement)
- HF
- HF1
- HF2
- HUS
- MGC88246
- NCBI_Gene: 3075
- UniProtKB: P08603
Human CFH Predicted Functions
Enables heparan sulfate proteoglycan binding activity; heparin binding activity; and identical protein binding activity. Involved in complement activation. Acts upstream of or within regulation of complement activation and regulation of complement-dependent cytotoxicity. Located in blood microparticle and extracellular exosome. Implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Biomarker of amphetamine abuse; atypical hemolytic-uremic syndrome; glaucoma; psoriasis; and squamous cell carcinoma.
Mouse Cfh Target Information
- Target Symbol: Cfh, complement component factor h
- Alias:
- Mud-1
- Sas-1
- Sas1
- serum antigenic substance 1
- NCBI_Gene: 12628
Mouse Cfh Predicted Functions
Enables complement component C3b binding activity and heparin binding activity. Acts upstream of or within several processes, including animal organ development; complement activation; and vasculature development. Located in several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including adrenal gland; bone; central nervous system; humerus cartilage condensation; and metanephros. Used to study age related macular degeneration 4; atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; and membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to several human genes including CFH (complement factor H).
Rat Cfh Target Information
- Target Symbol: Cfh, complement factor H
- Alias:
- adrenomedullin binding protein-1
- AMBP-1
- AMBP1
- complement component factor H
- complement inhibitory factor H
- Fh
- platelet complement factor H
- NCBI_Gene: 155012
Rat Cfh Predicted Functions
Predicted to enable several functions, including complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to interferon-gamma; and cellular response to lipopolysaccharide. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study atypical hemolytic-uremic syndrome. Biomarker of amphetamine abuse; membranous glomerulonephritis; obstructive jaundice; proteinuria (multiple); and retinal degeneration. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to several human genes including CFH (complement factor H).
