HGNC ID: 9053
Target Abstract:
The urokinase-type plasminogen activator receptor (uPAR) is a cell-surface receptor that binds urokinase-type plasminogen activator (uPA) with high affinity and thereby promotes plasminogen activation. It is a multidomain glycoprotein anchored to the cell membrane via GPI and was initially identified as a cell-surface urokinase saturation binding site. uPAR binds urokinase and restricts the activation of hemofibrinolysinogen closest to the periphery of the cell membrane. In addition to its primary ligand, urokinase, uPAR interacts with other proteins, among them blebbins, which are uPAR-associated proteins and integrin-family membrane proteins. uPAR is a part of the fibrinogen activation system, and is involved in tissue reorganization such as mammary gland degradation and wound healing in healthy organisms. uPAR is involved in other cancer-associated processes, such as cell migration, cell cycle regulation, and cell adhesion.
PLAUR Target Infomation Overview
- Target Symbol: PLAUR, plasminogen activator, urokinase receptor
- Gene Groups: CD molecules; LY6/PLAUR domain containing
- Alias: URKR; UPAR; CD87
- Alias Names: urokinase-type plasminogen activator (uPA) receptor; urokinase plasminogen activator surface receptor
PLAUR, plasminogen activator, urokinase receptor Target Infomation by Species
- Human
- Mouse
- Rat
Human PLAUR Target Information
- Target Symbol: PLAUR, plasminogen activator, urokinase receptor
- Alias:
- CD87
- monocyte activation antigen Mo3
- U-PAR
- u-plasminogen activator receptor form 2
- UPAR
- URKR
- urokinase plasminogen activator surface receptor
- urokinase-type plasminogen activator (uPA) receptor
- NCBI_Gene: 5329
- UniProtKB: Q03405
Human PLAUR Predicted Functions
Enables enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of apoptotic signaling pathway; positive regulation of epidermal growth factor receptor signaling pathway; and positive regulation of release of cytochrome c from mitochondria. Located in cell surface and plasma membrane. Implicated in rheumatoid arthritis. Biomarker of several diseases, including Lyme disease; cardiovascular system disease (multiple); end stage renal disease; hepatitis B; and melioidosis.
Mouse Plaur Target Information
- Target Symbol: Plaur, plasminogen activator, urokinase receptor
- Alias:
- Cd87
- u-PAR
- uPAR
- urokinase-type plasminogen activator receptor
- NCBI_Gene: 18793
Mouse Plaur Predicted Functions
Predicted to enable enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including negative regulation of apoptotic signaling pathway; positive regulation of epidermal growth factor receptor signaling pathway; and positive regulation of release of cytochrome c from mitochondria. Is integral component of plasma membrane. Is expressed in several structures, including decidua; early conceptus; and spleen. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human PLAUR (plasminogen activator, urokinase receptor).
Rat Plaur Target Information
- Target Symbol: Plaur, plasminogen activator, urokinase receptor
- Alias:
- Par
- plasminogen activator urokinase receptor 3
- plasminogen activator, urokinase receptor 3
- Plaur3
- U-PAR
- uPAR
- uPAR-2
- uPAR-3
- urinary plasminogen activator receptor 2
- urinary plasminogen activator receptor 3
- urokinase plasminogen activator receptor
- urokinase plasminogen activator surface receptor
- NCBI_Gene: 50692
Rat Plaur Predicted Functions
Predicted to enable enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in several processes, including epithelial cell differentiation involved in prostate gland development; skeletal muscle tissue regeneration; and spermatogenesis. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Biomarker of chronic obstructive pulmonary disease; myocardial infarction; and status epilepticus. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human PLAUR (plasminogen activator, urokinase receptor).
