HGNC ID: 6561
Target Abstract:
Galectins are a family of β-galactoside-binding proteins involved in the regulation of cell-cell and cell-matrix interactions.Galectin-1 can be either monomeric or homodimeric, and is present in a wide variety of cells and tissues. In humans, galectin-1 is a protein encoded by the LGALS1 gene. Secreted Galectin-1 is immunosuppressive and anti-inflammatory, inhibiting acute and chronic inflammation and autoimmunity. Mouse Galectin-1 has 88% sequence homology with human aa, 96% with rat aa, and 84% with equine, sheep, bovine, and porcine aa. Galectin-1 is highly expressed at the maternal-fetal interface and contributes to fetal immune amnesty. Its immunosuppressive properties also appear to allow tumor cells to evade immune detection.Galectin-1 regulates cell growth, proliferation, and induces apoptosis of activated T cells while modulating cytokine secretion or inhibiting pro-inflammatory cytokine production.
LGALS1 Target Infomation Overview
- Target Symbol: LGALS1, galectin 1
- Gene Groups: Receptor ligands; Galectins
- Alias: GBP
- Alias Names: lectin, galactoside-binding, soluble, 1
LGALS1, galectin 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human LGALS1 Target Information
- Target Symbol: LGALS1, galectin 1
- Alias:
- 14 kDa laminin-binding protein
- 14 kDa lectin
- beta-galactoside-binding lectin L-14-I
- beta-galactoside-binding protein 14kDa
- DKFZp686E23103
- gal-1
- GAL1
- galaptin
- galectin-1
- GBP
- HBL
- HLBP14
- HPL
- lactose-binding lectin 1
- lectin, galactoside binding soluble 1
- lectin, galactoside-binding, soluble, 1
- putative MAPK-activating protein PM12
- S-Lac lectin 1
- NCBI_Gene: 3956
- UniProtKB: P09382
Human LGALS1 Predicted Functions
Enables RNA binding activity. Involved in positive regulation of viral entry into host cell. Located in extracellular exosome. Colocalizes with collagen-containing extracellular matrix.
Mouse Lgals1 Target Information
- Target Symbol: Lgals1, lectin, galactose binding, soluble 1
- Alias:
- AA410090
- beta galactoside binding protein
- expressed sequence AA410090
- Gal-1
- Galbp
- galectin-1
- L14
- lactose binding soluble lectin, 14 kDa
- Lect14
- NCBI_Gene: 16852
Mouse Lgals1 Predicted Functions
Enables carbohydrate binding activity. Acts upstream of or within T cell costimulation; myoblast differentiation; and plasma cell differentiation. Located in extracellular space. Is expressed in several structures, including embryo mesenchyme; genitourinary system; integumental system; main olfactory bulb; and olfactory system. Orthologous to human LGALS1 (galectin 1).
Rat Lgals1 Target Information
- Target Symbol: Lgals1, galectin 1
- Alias:
- 14 kDa lectin
- beta-galactoside-binding lectin
- beta-galactoside-binding lectin L-14-I
- gal-1
- galaptin
- galectin-1
- lactose-binding lectin 1
- lectin, galactose binding, soluble 1
- lectin, galactoside-binding, soluble, 1
- RL 14.5
- S-Lac lectin 1
- NCBI_Gene: 56646
- UniProtKB: P11762
Rat Lgals1 Predicted Functions
Enables identical protein binding activity; lactose binding activity; and laminin binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of erythrocyte aggregation; and response to isolation stress. Located in cell surface; cytosol; and nucleus. Biomarker of B-cell lymphoma; extrahepatic cholestasis; and lipoid nephrosis. Orthologous to human LGALS1 (galectin 1).
