HGNC ID: 19157
Target Abstract:
Interleukin 27 (IL-27), a member of the IL-12 family, is a heterodimeric protein consisting of two subunits, Epstein-Barr virus (EBV)-inducible gene 3 (EBI3, also known as IL-27B) and IL-27p28 (known as IL-30).IL-27 is produced by antigen-presenting cells and plays an important role in regulating the activity of B and T lymphocytes. IL-27 exerts its effects by interacting with a specific cell surface receptor complex composed of two proteins, IL-27R and gp130.IL-27 has proinflammatory and anti-inflammatory properties. In response to infection, IL-27 induces the secretion of proinflammatory cytokines by monocytes and mast cells, which induce the proliferation of naïve CD4+ T cells and elicit a Th1 cell response.IL-27 also promotes the effector functions of NK cells and CD8+ T cells. As an anti-inflammatory immunomodulator, IL-27 inhibits Th1 or Th2 responses and limits the intensity and duration of adaptive immune responses. Recent studies have shown that IL-27 has good antitumor activity, and IL-27 has been reported to be actively involved in the induction of inflammation in rheumatoid arthritis.
IL27 Target Infomation Overview
- Target Symbol: IL27, interleukin 27
- Gene Groups: Interleukins
- Alias: IL-27; p28; IL27p28; IL-27A; IL27A; MGC71873
- Previous Names: IL30
- Alias Names: interleukin 30
IL27, interleukin 27 Target Infomation by Species
- Human
- Mouse
- Rat
Human IL27 Target Information
- Target Symbol: IL27, interleukin 27
- Alias:
- IL-27
- IL-27 p28 subunit
- IL-27 subunit alpha
- IL-27-A
- IL-27A
- IL27-A
- IL27A
- IL27p28
- IL30
- interleukin 30
- interleukin-27 subunit alpha
- interleukin-30
- MGC71873
- p28
- NCBI_Gene: 246778
- UniProtKB: Q8NEV9
Human IL27 Predicted Functions
Predicted to enable interleukin-27 receptor binding activity. Involved in positive regulation of interferon-gamma production and regulation of T-helper 1 cell differentiation. Predicted to be located in cytosol; endoplasmic reticulum lumen; and extracellular region. Predicted to be active in extracellular space. Implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Biomarker of several diseases, including Henoch-Schoenlein purpura; hepatitis B; infectious mononucleosis; peptic ulcer disease (multiple); and tuberculosis (multiple).
Mouse Il27 Target Information
- Target Symbol: Il27, interleukin 27
- Alias:
- IL-27
- IL-27p28
- Il30
- interleukin 30
- p28
- NCBI_Gene: 246779
Mouse Il27 Predicted Functions
Enables interleukin-27 receptor binding activity. Acts upstream of or within positive regulation of defense response to virus by host and regulation of T cell proliferation. Located in extracellular space. Is expressed in decidua; embryo; and extraembryonic component. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Orthologous to human IL27 (interleukin 27).
Rat Il27 Target Information
- Target Symbol: Il27, interleukin 27
- Alias:
- interleukin-27 subunit alpha
- LOC365368
- RGD1561420
- similar to IL-27 p28 subunit
- NCBI_Gene: 365368
- UniProtKB: D3ZPW3
Rat Il27 Predicted Functions
Predicted to enable interleukin-27 receptor binding activity. Involved in response to bacterium. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Orthologous to human IL27 (interleukin 27).
