Target Abstract: Interleukin-10 Receptor Beta Subunit (IL10RB/IL-10RB), also known as Cytokine Receptor Family 2 Member 4, Interleukin-10 Receptor Second Subunit, and Cytokine Receptor Family II Member 4, is a key component of the interleukin-10 receptor. Belonging to the cytokine receptor family, this protein serves as an essential accessory chain for forming functional interleukin-10 receptor complexes. Its co-expression with the IL10RA protein is a necessary condition for IL-10-induced signal transduction. Genetic defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). This is a chronic relapsing gastrointestinal inflammation with complex etiologies, mainly classified into two clinical types: Crohn's disease and ulcerative colitis. Crohn's disease can involve the entire digestive tract from the oral cavity to the anus, most commonly affecting the terminal ileum and colon. It is characterized by transmural, discontinuous inflammation, which may be accompanied by granulomas or intestinal/perianal fistulas. Ulcerative colitis, however, presents as continuous inflammation confined to the mucosal layer of the rectum and colon, usually without fistulas or granulomas. Both diseases may lead to extraintestinal inflammatory manifestations such as those involving the skin, eyes, or joints.

IL1R2 Target Infomation Overview

• Target Symbol: IL1R2, interleukin 1 receptor type 2
• Gene Groups: Interleukin receptors; CD molecules; Immunoglobulin like domain containing
• Alias: CD121b; IL1RB
• Alias Names: interleukin 1 receptor, type II

IL1R2 Target Infomation by Species