HGNC ID: 10647
Target Abstract:
Chemokine (C-X3-C motif) ligand 1 (CX3CL1), also known as fractalkine, is a macromolecular cytokine protein consisting of 373 amino acids and the only known member of the CX3C chemokine family. Soluble CX3CL1 is present in serum, urine, cerebrospinal fluid, amniotic fluid, and synovial fluid, and is expressed primarily by vascular endothelium, smooth muscle, neurons, and dendritic cells. Inflammatory cytokines such as TNF-α and IFN-γ induce most of the expression of CX3CL1.CX3CL1 exerts its adhesion and migration functions through interaction with the chemokine receptor CX3CR1. Soluble CX3XL1 strongly chemotaxis T cells and monocytes, whereas cell-bound chemokines promote strong adhesion of leukocytes to activated endothelial cells.CX3CL1 may be associated with antitumor activity and has an important role in abrogating normal inflammatory processes, such as wound healing.CX3CL1 is known to be a facilitator of the pathogenesis of certain conditions.
CX3CL1 Target Infomation Overview
- Target Symbol: CX3CL1, C-X3-C motif chemokine ligand 1
- Gene Groups: Chemokine ligands
- Alias: NTN; C3Xkine; ABCD-3; CXC3C; CXC3
- Previous Names: SCYD1
- Alias Names: fractalkine; neurotactin; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); chemokine (C-X3-C motif) ligand 1
CX3CL1, C-X3-C motif chemokine ligand 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human CX3CL1 Target Information
- Target Symbol: CX3CL1, C-X3-C motif chemokine ligand 1
- Alias:
- ABCD-3
- C-X3-C motif chemokine 1
- C3Xkine
- chemokine (C-X3-C motif) ligand 1
- CX3C membrane-anchored chemokine
- CXC3
- CXC3C
- fractalkine
- neurotactin
- NTN
- NTT
- SCYD1
- small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin)
- small inducible cytokine subfamily D (Cys-X3-Cys), member-1
- small-inducible cytokine D1
- NCBI_Gene: 6376
- UniProtKB: P78423
Human CX3CL1 Predicted Functions
Enables signaling receptor binding activity. Involved in several processes, including regulation of cell migration; regulation of gene expression; and regulation of signal transduction. Located in cell surface; extracellular region; and membrane. Is integral component of membrane. Implicated in Cor pulmonale and common cold. Biomarker of several diseases, including chronic fatigue syndrome; myositis (multiple); polyarteritis nodosa; pulmonary hypertension; and rheumatoid arthritis.
Mouse Cx3cl1 Target Information
- Target Symbol: Cx3cl1, chemokine (C-X3-C motif) ligand 1
- Alias:
- AB030188
- AI848747
- CX3C
- D8Bwg0439e
- DNA segment, Chr 8, Brigham & Women’s Genetics 0439 expressed
- expressed sequence AI848747
- fractalkine
- hypothetical protein, clone 1-53
- neurotactin
- Scyd1
- small inducible cytokine subfamily D, 1
- NCBI_Gene: 20312
Mouse Cx3cl1 Predicted Functions
Enables CX3C chemokine receptor binding activity and chemokine activity. Acts upstream of or within several processes, including angiogenesis involved in wound healing; leukocyte chemotaxis; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Is expressed in several structures, including brain; genitourinary system; gut; nose; and respiratory system. Human ortholog(s) of this gene implicated in Cor pulmonale and common cold. Orthologous to human CX3CL1 (C-X3-C motif chemokine ligand 1).
Rat Cx3cl1 Target Information
- Target Symbol: Cx3cl1, C-X3-C motif chemokine ligand 1
- Alias:
- C-X3-C motif chemokine 1
- chemokine (C-X3-C motif) ligand 1
- Cx3c
- CX3C membrane-anchored chemokine
- fractalkine
- neurotactin
- Scyd1
- small inducible cytokine subfamily D 1
- small inducible cytokine subfamily D, 1
- small-inducible cytokine D1
- NCBI_Gene: 89808
Rat Cx3cl1 Predicted Functions
Enables chemokine activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of gene expression; and regulation of signal transduction. Located in several cellular components, including neuron projection; neuronal cell body; and perinuclear region of cytoplasm. Used to study acute pancreatitis; ischemia; and status epilepticus. Biomarker of several diseases, including borna disease; brain disease (multiple); liver disease (multiple); lung disease (multiple); and pulmonary hypertension. Human ortholog(s) of this gene implicated in Cor pulmonale and common cold. Orthologous to human CX3CL1 (C-X3-C motif chemokine ligand 1).
