HGNC ID: 3396
Target Abstract:
According to their structure and sequence relationships, Ephrins can be divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class. Ephrin receptors are the largest subgroup in the receptor tyrosine kinase (RTK) family. EphrinB type receptor 6 (EphB6) is an unusual Eph receptor that lacks catalytic ability due to changes in its kinase domain. EphB6 can regulate cell adhesion and migration in both positive and negative directions. Additionally, Ephrin-B2 may be a physiological ligand for the EphB6 receptor. In some tumor types, including breast cancer, the increase of metastasis activity is related to the decrease of EphB6 receptor expression, which indicates that EphB6 may be used as an inhibitor of cancer invasion. EphB6 inhibits cancer invasion through c-Cbl dependent signaling, morphological changes, and cell adhesion, indicating that EphB6 may be a useful prognostic indicator and therapeutic target.
EPHB6 Target Infomation Overview
- Target Symbol: EPHB6, EPH receptor B6
- Gene Groups: Sterile alpha motif domain containing; EPH receptors
- Alias: HEP
- Alias Names: EphB6
EPHB6, EPH receptor B6 Target Infomation by Species
- Human
- Mouse
- Rat
Human EPHB6 Target Information
- Target Symbol: EPHB6, EPH receptor B6
- Alias:
- ephrin type-B receptor 6
- HEP
- human kinase-defective Eph-family receptor protein
- MGC129910
- MGC129911
- tyrosine-protein kinase-defective receptor EPH-6
- NCBI_Gene: 2051
- UniProtKB: O15197
Human EPHB6 Predicted Functions
Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axonogenesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Predicted to be located in cytosol; extracellular region; and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane.
Mouse Ephb6 Target Information
- Target Symbol: Ephb6, Eph receptor B6
- Alias:
- Cekl
- chicken eph/elk receptor-like protein
- Mep
- NCBI_Gene: 13848
Mouse Ephb6 Predicted Functions
Predicted to enable transmembrane-ephrin receptor activity. Acts upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; integumental system; intraembryonic coelom; and sensory organ. Orthologous to human EPHB6 (EPH receptor B6).
Rat Ephb6 Target Information
- Target Symbol: Ephb6, Eph receptor B6
- Alias:
- ephrin type-B receptor 6
- LOC102554290
- LOC312275
- serine/arginine repetitive matrix protein 2-like
- tyrosine-protein kinase-defective receptor EPH-6
- NCBI_Gene: 312275
- UniProtKB: P0C0K7
Rat Ephb6 Predicted Functions
Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axonogenesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human EPHB6 (EPH receptor B6).
