HGNC ID: 10720
Target Abstract:
L-selectin, also known as CD62L, is a cell surface glycoprotein that is constitutively expressed in a variety of leukocytes. It is a cell adhesion molecule present in lymphocytes and preimplantation embryos and is a member of the selectin family of proteins. Studies have reported the existence of two forms of soluble L-selectin (sL-Selectin). sL-Selectin is derived from lymphocytes and has a molecular weight of approximately 62 kDa, whereas sL-Selectin derived from neutrophils has a molecular weight of 75-100 kDa. sL-Selectin at high concentrations prevents lymphocytes from binding to the endothelium, suggesting a role for sL-Selectin in regulating cell adhesion in the body. Selectin may play a role in regulating lymphocyte-endothelial binding in vivo. Monitoring serum levels of sL-Selectin may provide more detailed insight into some pathologies such as sepsis and acquired immunodeficiency syndrome (AIDS).
SELL Target Infomation Overview
- Target Symbol: SELL, selectin L
- Gene Groups: CD molecules; Selectins; Sushi domain containing; C-type lectin domain containing
- Alias: LSEL; LAM1; LAM-1; hLHRc; Leu-8; Lyam-1; PLNHR; CD62L
- Previous Names: LYAM1; LNHR
- Alias Names: lymphocyte adhesion molecule 1
SELL, selectin L Target Infomation by Species
- Human
- Mouse
- Rat
Human SELL Target Information
- Target Symbol: SELL, selectin L
- Alias:
- CD62 antigen-like family member L
- CD62L
- gp90-MEL
- hLHRc
- L-selectin
- LAM-1
- LAM1
- LECAM1
- Leu-8
- LEU8
- leukocyte adhesion molecule 1
- leukocyte surface antigen Leu-8
- leukocyte-endothelial cell adhesion molecule 1
- LNHR
- LSEL
- Lyam-1
- LYAM1
- lymph node homing receptor
- lymphocyte adhesion molecule 1
- pln homing receptor
- PLNHR
- TQ1
- NCBI_Gene: 6402
- UniProtKB: P14151
Human SELL Predicted Functions
Enables calcium ion binding activity; oligosaccharide binding activity; and protease binding activity. Involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules and leukocyte tethering or rolling. Is integral component of plasma membrane. Implicated in Crohn’s disease; IgA glomerulonephritis; and ulcerative colitis. Biomarker of Alzheimer’s disease; IgA glomerulonephritis; and systemic lupus erythematosus.
Mouse Sell Target Information
- Target Symbol: Sell, selectin, lymphocyte
- Alias:
- AI528707
- CD62L
- expressed sequence AI528707
- L-selectin
- LECAM-1
- Lnhr
- Ly-22
- Ly-m22
- Lyam-1
- Lyam1
- lymph node homing receptor
- lymphocyte adhesion molecule 1
- lymphocyte antigen 22
- lymphocyte antigen m22
- NCBI_Gene: 20343
Mouse Sell Predicted Functions
Enables cell adhesion molecule binding activity. Acts upstream of or within response to ATP. Located in external side of plasma membrane. Is expressed in brain; brainstem; submandibular gland epithelium; and testis. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in Crohn’s disease; IgA glomerulonephritis; and ulcerative colitis. Orthologous to human SELL (selectin L).
Rat Sell Target Information
- Target Symbol: Sell, selectin L
- Alias:
- A.11
- CD62 antigen-like family member L
- L-selectin
- LAM-1
- LECAM-1
- LECAM1
- leukocyte adhesion molecule 1
- leukocyte-endothelial cell adhesion molecule 1
- ly-22
- lymph node homing receptor
- lymphocyte antigen 22
- lymphocyte surface MEL-14 antigen
- selectin, lymphocyte
- NCBI_Gene: 29259
Rat Sell Predicted Functions
Enables glycolipid binding activity. Involved in several processes, including positive regulation of neutrophil chemotaxis; response to fatty acid; and response to hyperoxia. Located in cell surface. Used to study colitis and peripheral vascular disease. Biomarker of abdominal aortic aneurysm; endometriosis; pancreatitis; and toxic shock syndrome. Human ortholog(s) of this gene implicated in Crohn’s disease; IgA glomerulonephritis; and ulcerative colitis. Orthologous to human SELL (selectin L).
