HGNC ID: 2438
Target Abstract:
Granulocyte colony stimulating factor (G-CSF) is a glycoprotein that stimulates the production of granulocytes and stem cells in the bone marrow and releases them into the bloodstream. Functionally, it is a cytokine and hormone, a colony stimulating factor produced by endothelial cells, macrophages, and many other immune cells. G-CSF stimulates the survival, proliferation, differentiation, and functional development of neutrophil precursors and mature neutrophils. In oncology and hematology, recombinant G-CSF is used to accelerate the recovery of neutropenia caused by chemotherapy in cancer patients. Before removing white blood cells, G-CSF can also be used to increase the number of hematopoietic stem cells in the blood of blood donors for hematopoietic stem cell transplantation.
CSF3 Target Infomation Overview
- Target Symbol: CSF3, colony stimulating factor 3
- Gene Groups: Receptor ligands
- Alias: MGC45931
- Previous Names: GCSF; G-CSF; C17orf33
- Alias Names: granulocyte colony stimulating factor; pluripoietin; filgrastim; lenograstim; chromosome 17 open reading frame 33; colony stimulating factor 3 (granulocyte)
CSF3, colony stimulating factor 3 Target Infomation by Species
- Human
- Mouse
- Rat
Human CSF3 Target Information
- Target Symbol: CSF3, colony stimulating factor 3
- Alias:
- C17orf33
- chromosome 17 open reading frame 33
- colony stimulating factor 3 (granulocyte)
- CSF3OS
- filgrastim
- G-CSF
- GCSF
- granulocyte colony-stimulating factor
- granulocyte-colony stimulating factor
- lenograstim
- MGC45931
- pluripoietin
- NCBI_Gene: 1440
- UniProtKB: P09919
Human CSF3 Predicted Functions
Enables cytokine activity and enzyme binding activity. Involved in several processes, including positive regulation of cytoskeleton organization; positive regulation of intracellular signal transduction; and positive regulation of protein phosphorylation. Predicted to be located in endocytic vesicle lumen; extracellular region; and lysosomal lumen. Predicted to be active in extracellular space. Implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Biomarker of COVID-19; bacterial pneumonia; and myeloid leukemia.
Mouse Csf3 Target Information
- Target Symbol: Csf3, colony stimulating factor 3 (granulocyte)
- Alias:
- colony stimulating factor, granulocyte
- Csfg
- G-CSF
- MGI-IG
- NCBI_Gene: 12985
Mouse Csf3 Predicted Functions
Enables granulocyte colony-stimulating factor receptor binding activity. Acts upstream of or within positive regulation of myeloid cell differentiation. Predicted to be located in endocytic vesicle lumen and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; dorsal aorta; liver; reproductive system; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human CSF3 (colony stimulating factor 3).
Rat Csf3 Target Information
- Target Symbol: Csf3, colony stimulating factor 3
- Alias:
- colony stimulating factor 3 (granulocyte)
- Gcsf
- granulocyte colony-stimulating factor
- NCBI_Gene: 25610
- UniProtKB: P97712
Rat Csf3 Predicted Functions
Enables growth factor activity. Involved in several processes, including cellular response to lipopolysaccharide; negative regulation of neuron death; and response to ethanol. Located in extracellular space. Biomarker of cystitis; lung disease; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human CSF3 (colony stimulating factor 3).
