HGNC ID: 1071
Target Abstract:
BMP (Bone Morphogenetic Protein) is a secreted signaling molecule and a subfamily of the TGF-β (Transforming Growth Factor-beta) superfamily. Initially identified as regulators of cartilage and bone formation, BMPs are typically involved in embryonic development and morphogenesis of various tissues and organs. BMP-2, BMP-4, and BMP-7 function in the regulation of hematopoietic tissue specification in the mesoderm. They regulate the proliferation and differentiation of highly purified primitive human hematopoietic cells derived from both adults and neonates. BMP-4, also known as Bone Morphogenetic Protein 4, forms a homodimer linked by disulfide bonds. It has been shown that BMP-4 is also involved in the differentiation of sympathetic neurons, enhancing the formation of adrenergic sympathetic neurons in neural cell cultures.
BMP4 Target Infomation Overview
- Target Symbol: BMP4, bone morphogenetic protein 4
- Gene Groups: Bone morphogenetic proteins
- Previous Names: BMP2B
BMP4, bone morphogenetic protein 4 Target Infomation by Species
- Human
- Mouse
- Rat
Human BMP4 Target Information
- Target Symbol: BMP4, bone morphogenetic protein 4
- Alias:
- BMP-2B
- BMP-4
- BMP2B
- BMP2B1
- bone morphogenetic protein 2B
- bone morphogenetic protein 4 preproprotein
- MCOPS6
- OFC11
- ZYME
- NCBI_Gene: 652
- UniProtKB: P12644
Human BMP4 Predicted Functions
Enables BMP receptor binding activity; co-receptor binding activity; and receptor ligand activity. Involved in several processes, including animal organ development; negative regulation of cell population proliferation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including positive regulation of osteoblast differentiation; regulation of transcription by RNA polymerase II; and respiratory system development. Located in extracellular space. Implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Biomarker of several diseases, including Barrett’s esophagus; eye disease (multiple); myositis ossificans; progressive osseous heteroplasia; and prolactinoma.
Mouse Bmp4 Target Information
- Target Symbol: Bmp4, bone morphogenetic protein 4
- Alias:
- Bmp-4
- Bmp2b
- Bmp2b-1
- Bmp2b1
- bone morphogenetic protein 2b
- bone morphogenetic protein 2b 1
- NCBI_Gene: 12159
Mouse Bmp4 Predicted Functions
Enables heparin binding activity. Involved in several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of morphogenesis of a branching structure. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of animal organ morphogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Axenfeld-Rieger syndrome type 3; atrioventricular septal defect; cleft palate-lateral synechia syndrome; fibrodysplasia ossificans progressiva; and urinary system disease. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4).
Rat Bmp4 Target Information
- Target Symbol: Bmp4, bone morphogenetic protein 4
- Alias:
- BMP-2B
- BMP-4
- BOMPR4A
- bone morphogenetic protein 2B
- NCBI_Gene: 25296
Rat Bmp4 Predicted Functions
Enables growth factor activity and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of calcium ion transport; and positive regulation of cell differentiation. Acts upstream of or within positive regulation of ossification and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; extracellular space; and vesicle. Biomarker of Barrett’s esophagus; congenital diaphragmatic hernia; epilepsy; peptic esophagitis; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4).
