HGNC ID: 7941
Target Abstract:
C-Peptide (C-peptide), also known as linking peptide, is secreted by islet beta cells and shares a common precursor with insulin. It is A polypeptide composed of 31 amino acids that connects the A and B chains of insulin in the proinsulin molecule. C-peptide has been shown to bind at nanomolar concentrations to G-protein-coupled receptors on the surface of many cell types, such as neurons, endothelial cells, fibroblasts, and renal tubules. C-peptide plays an anti-inflammatory role by down-regulating endothelial cell surface adhesion molecules, reducing inflammatory cytokine production and protecting vascular smooth muscle cells from harmful insulin action. In animals with C-peptide-deficient (type 1 model) nephropathy, administration of C-peptide improves renal function and structure, reduces urinary albumin excretion, and also prevents or reduces glomerular changes due to diabetes with mesangial stroma dilatation.
NPPC Target Infomation Overview
- Target Symbol: NPPC, natriuretic peptide C
- Gene Groups: Neuropeptides
- Alias: CNP
- Alias Names: natriuretic peptide precursor C
NPPC, natriuretic peptide C Target Infomation by Species
- Human
- Mouse
- Rat
Human NPPC Target Information
- Target Symbol: NPPC, natriuretic peptide C
- Alias:
- C-type natriuretic peptide
- CNP
- CNP2
- natriuretic peptide precursor C
- natriuretic peptide precursor type C
- NCBI_Gene: 4880
- UniProtKB: P23582
Human NPPC Predicted Functions
Enables hormone receptor binding activity. Involved in protein folding and receptor guanylyl cyclase signaling pathway. Acts upstream of or within negative regulation of meiotic cell cycle and negative regulation of oocyte maturation. Part of protein-containing complex. Implicated in hypertension. Biomarker of arteriosclerosis; end stage renal disease; hypertension; and toxic shock syndrome.
Mouse Nppc Target Information
- Target Symbol: Nppc, natriuretic peptide type C
- Alias:
- CNP
- lbab
- long bone abnormality
- natriuretic peptide precursor C
- NCBI_Gene: 18159
Mouse Nppc Predicted Functions
Enables signaling receptor binding activity. Involved in growth plate cartilage chondrocyte differentiation and growth plate cartilage chondrocyte proliferation. Acts upstream of or within several processes, including negative regulation of meiotic cell cycle; negative regulation of oocyte maturation; and regulation of growth. Predicted to be located in extracellular space and secretory granule. Predicted to be part of protein-containing complex. Is expressed in central nervous system and vertebral cartilage condensation. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPPC (natriuretic peptide C).
Rat Nppc Target Information
- Target Symbol: Nppc, natriuretic peptide C
- Alias:
- C-type natriuretic peptide
- natriuretic peptide precursor C
- natriuretic peptide precursor type C
- NCBI_Gene: 114593
- UniProtKB: P55207
Rat Nppc Predicted Functions
Enables hormone activity. Involved in several processes, including negative regulation of biosynthetic process; positive regulation of cGMP-mediated signaling; and positive regulation of osteoblast differentiation. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in extracellular space and secretory granule. Biomarker of aortic valve stenosis and heart disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPPC (natriuretic peptide C).
