HGNC ID: 11927
Target Abstract:
tumor necrosis factor-like weak inducer of apoptosis (TWEAK) was discovered in 1997. The protein encoded by the TWEAK gene is a cytokine in the tumor necrosis factor (TNF) ligand family. White cells (including human resting and activated monocytes, dendritic cells, and natural killer cells) are the main source of TWEAK. TWEAK can induce apoptosis through a variety of pathways, depending on the cell type, and can also promote the proliferation and migration of endothelial cells, thus playing a role in regulating angiogenesis. In chronic injury, over-activated TWEAK pathways can promote pathological tissue changes, including chronic inflammation, fibrosis, and angiogenesis.
TNFSF12 Target Infomation Overview
- Target Symbol: TNFSF12, TNF superfamily member 12
- Gene Groups: Tumor necrosis factor superfamily
- Alias: TWEAK; DR3LG; APO3L
- Alias Names: tumor necrosis factor (ligand) superfamily, member 12
TNFSF12, TNF superfamily member 12 Target Infomation by Species
- Human
- Mouse
- Rat
Human TNFSF12 Target Information
- Target Symbol: TNFSF12, TNF superfamily member 12
- Alias:
- APO3 ligand
- APO3/DR3 ligand
- APO3L
- DR3LG
- MGC129581
- MGC20669
- TNF-related WEAK inducer of apoptosis
- TNLG4A
- tumor necrosis factor (ligand) superfamily member 12
- tumor necrosis factor (ligand) superfamily, member 12
- tumor necrosis factor ligand 4A
- tumor necrosis factor ligand superfamily member 12
- tumor necrosis factor superfamily member 12
- TWEAK
- NCBI_Gene: 8742
- UniProtKB: O43508
Human TNFSF12 Predicted Functions
Predicted to enable receptor ligand activity. Involved in positive regulation of extrinsic apoptotic signaling pathway. Acts upstream of or within positive regulation of protein catabolic process. Located in perinuclear region of cytoplasm.
Mouse Tnfsf12 Target Information
- Target Symbol: Tnfsf12, tumor necrosis factor (ligand) superfamily, member 12
- Alias:
- APO3L
- DR3L
- TNF-related weak inducer of apoptosis
- Tweak
- NCBI_Gene: 21944
Mouse Tnfsf12 Predicted Functions
Predicted to enable receptor ligand activity. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in extracellular region. Is expressed in Meckel’s cartilage; hip; skeleton; and superior cervical ganglion. Orthologous to several human genes including TNFSF12-TNFSF13 (TNFSF12-TNFSF13 readthrough).
Rat Tnfsf12 Target Information
- Target Symbol: Tnfsf12, TNF superfamily member 12
- Alias:
- TNF-related weak inducer of apoptosis
- Tnlg4a
- tumor necrosis factor ligand 4a
- tumor necrosis factor ligand superfamily member 12
- tumor necrosis factor superfamily member 12
- TWEAK
- NCBI_Gene: 360548
Rat Tnfsf12 Predicted Functions
Predicted to enable receptor ligand activity. Predicted to be involved in extrinsic apoptotic signaling pathway and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within positive regulation of protein catabolic process. Predicted to be located in extracellular region and perinuclear region of cytoplasm. Predicted to be active in extracellular space. Orthologous to several human genes including TNFSF12-TNFSF13 (TNFSF12-TNFSF13 readthrough).
