HGNC ID: 11763
Target Abstract:
The transferrin receptor CD71 is a 1180 kDa type II transmembrane protein that exists on the cell surface in the form of homologous dimers and is essential for cell growth. CD71 is expressed in immature proliferating cells and is less expressed in resting mature lymphocytes. T cells and B cells stimulated by antigen or mitogen can up-regulate CD71 expression.
TFRC Target Infomation Overview
- Target Symbol: TFRC, transferrin receptor
- Gene Groups: CD molecules; M28 metallopeptidases
- Alias: CD71; TFR1; p90
- Alias Names: transferrin receptor (p90, CD71)
TFRC, transferrin receptor Target Infomation by Species
- Human
- Mouse
- Rat
Human TFRC Target Information
- Target Symbol: TFRC, transferrin receptor
- Alias:
- CD71
- IMD46
- p90
- T9
- TFR
- TFR1
- TR
- transferrin receptor (p90, CD71)
- transferrin receptor protein 1
- TRFR
- NCBI_Gene: 7037
- UniProtKB: P02786
Human TFRC Predicted Functions
Enables several functions, including double-stranded RNA binding activity; protein homodimerization activity; and transferrin receptor activity. Involved in several processes, including negative regulation of mitochondrial fusion; positive regulation of NF-kappaB transcription factor activity; and positive regulation of lymphocyte activation. Acts upstream of or within cellular response to xenobiotic stimulus. Located in several cellular components, including basolateral plasma membrane; clathrin-coated pit; and endosome. Is integral component of plasma membrane. Part of HFE-transferrin receptor complex. Implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Biomarker of breast cancer; carcinoma (multiple); iron deficiency anemia; and prostate cancer.
Mouse Tfrc Target Information
- Target Symbol: Tfrc, transferrin receptor
- Alias:
- 2610028K12Rik
- AI195355
- AI426448
- AU015758
- CD71
- E430033M20Rik
- expressed sequence AI195355
- expressed sequence AI426448
- expressed sequence AU015758
- mammary tumor virus receptor 1
- Mtvr-1
- Mtvr1
- p90
- RIKEN cDNA 2610028K12 gene
- RIKEN cDNA E430033M20 gene
- TfR1
- Trfr
- NCBI_Gene: 22042
Mouse Tfrc Predicted Functions
Predicted to enable several functions, including Hsp70 protein binding activity; chaperone binding activity; and protein homodimerization activity. Involved in osteoclast differentiation; positive regulation of bone resorption; and positive regulation of lymphocyte proliferation. Acts upstream of or within cellular iron ion homeostasis and cellular response to leukemia inhibitory factor. Located in several cellular components, including clathrin-coated pit; endosome; and extracellular exosome. Part of HFE-transferrin receptor complex. Is expressed in several structures, including alimentary system; extraembryonic component; liver; lung; and meninges. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor).
Rat Tfrc Target Information
- Target Symbol: Tfrc, transferrin receptor
- Alias:
- tfR
- tfR1
- TR
- transferrin receptor protein 1
- Trfr
- NCBI_Gene: 64678
Rat Tfrc Predicted Functions
Enables Hsp70 protein binding activity; chaperone binding activity; and transferrin receptor activity. Involved in several processes, including response to copper ion; response to manganese ion; and response to retinoic acid. Located in several cellular components, including cell surface; extracellular exosome; and recycling endosome membrane. Biomarker of duodenal ulcer; hepatocellular carcinoma; muscular atrophy; non-alcoholic fatty liver disease; and nutrition disease. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor).
