HGNC ID: 333
Target Abstract:
Angiotensinogen (AGT), also known as SerpinA8, is a member of the serine protease inhibitor family. AGT is an α-2-globulin produced and released into the circulation by the liver. AGT is an essential component of the renin-angiotensin system and is an effective blood pressure regulator. AGT can be cleaved into three chains: angiotensin-1, angiotensin-2, and angiotensin-3. The absence of AGT is associated with primary hypertension and renal tubular dysgenesis. Some serine protease inhibitors, such as antithrombin, maspin, pigment epithelium-derived factor, and kallistatin, have recently been shown to have antiangiogenic activity, indicating a common mechanism for endothelial cell proliferation and migration. AGT and its renin-cleavage products are also angiogenesis inhibitors within the plasma concentration range observed in vitro and in vivo.
AGT Target Infomation Overview
- Target Symbol: AGT, angiotensinogen
- Gene Groups: Serpin peptidase inhibitors; Neuropeptides
- Previous Names: SERPINA8
- Alias Names: alpha-1 antiproteinase, antitrypsin; serpin peptidase inhibitor, clade A, member 8
AGT, angiotensinogen Target Infomation by Species
- Human
- Mouse
- Rat
Human AGT Target Information
- Target Symbol: AGT, angiotensinogen
- Alias:
- alpha-1 antiproteinase, antitrypsin
- angiotensin I
- angiotensin II
- angiotensinogen (serine (or cysteine) proteinase inhibitor, clade a (alpha-1 antiproteinase, antitrypsin), member 8)
- angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
- ANHU
- fetal-liver predominant transporter 1
- FLJ92595
- FLJ97926
- hFLT1
- pre-angiotensinogen
- serine (or cysteine) proteinase inhibitor
- serpin A8
- serpin peptidase inhibitor, clade A, member 8
- SERPINA8
- NCBI_Gene: 183
- UniProtKB: P01019
Human AGT Predicted Functions
Enables angiotensin receptor binding activity; receptor ligand activity; and sodium channel regulator activity. Involved in several processes, including positive regulation of peptidyl-tyrosine phosphorylation; regulation of gene expression; and regulation of signal transduction. Located in extracellular space. Part of collagen-containing extracellular matrix. Implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Biomarker of several diseases, including alcoholic hepatitis; chronic myeloid leukemia; intermediate coronary syndrome; systemic scleroderma (multiple); and type 2 diabetes mellitus.
Mouse Agt Target Information
- Target Symbol: Agt, angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
- Alias:
- AI265500
- angiotensin precursor
- Aogen
- expressed sequence AI265500
- Serpina8
- NCBI_Gene: 11606
Mouse Agt Predicted Functions
Enables type 1 angiotensin receptor binding activity and type 2 angiotensin receptor binding activity. Involved in positive regulation of cytokine production. Acts upstream of or within several processes, including nervous system development; positive regulation of protein phosphorylation; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is expressed in several structures, including axial skeleton; central nervous system; foregut mesenchyme; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen).
Rat Agt Target Information
- Target Symbol: Agt, angiotensinogen
- Alias:
- Ang
- AngII
- angiotensin II
- angiotensinogen (PAT)
- angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
- ANRT
- MGC105326
- PAT
- serpin A8
- NCBI_Gene: 24179
- UniProtKB: P01015
Rat Agt Predicted Functions
Enables hormone activity. Involved in several processes, including MAPK cascade; regulation of ion transport; and regulation of secretion. Located in cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); diabetic retinopathy; gastric ulcer; impotence; and sciatic neuropathy. Biomarker of several diseases, including cerebrovascular disease (multiple); glomerulonephritis (multiple); liver cirrhosis (multiple); lung disease (multiple); and prediabetes syndrome. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen).
