HGNC ID: 1371
Target Abstract:
Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Carbonic anhydrases are involved in various biological processes, including respiration, calcification, acid-base balance, bone resorption, as well as the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.Carbonic anhydrase 12 (CA12) is a type I membrane protein that is highly expressed in normal tissues such as the kidney, colon, and pancreas, and is overexpressed in 10% of renal clear cell carcinomas. Two transcript variants encoding different isoforms of CA12 have been identified. Researchers suggest that genetic mutations in CA12 may be associated with autosomal recessive inherited hyponatremia, as sweating leads to salt depletion.
CA12 Target Infomation Overview
- Target Symbol: CA12, carbonic anhydrase 12
- Gene Groups: Carbonic anhydrases
- Alias: HsT18816
- Alias Names: carbonic anhydrase XII
CA12, carbonic anhydrase 12 Target Infomation by Species
- Human
- Mouse
- Rat
Human CA12 Target Information
- Target Symbol: CA12, carbonic anhydrase 12
- Alias:
- CA-XII
- carbonate dehydratase XII
- carbonic anhydrase XII
- carbonic dehydratase
- CAXII
- FLJ20151
- HsT18816
- T18816
- tumor antigen HOM-RCC-3.1.3
- NCBI_Gene: 771
- UniProtKB: O43570
Human CA12 Predicted Functions
Predicted to enable carbonate dehydratase activity. Involved in chloride ion homeostasis. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Implicated in isolated hyperchlorhidrosis.
Mouse Car12 Target Information
- Target Symbol: Car12, carbonic anhydrase 12
- Alias:
- 2310047E01Rik
- AI314958
- CA XII
- expressed sequence AI314958
- RIKEN cDNA 2310047E01 gene
- NCBI_Gene: 76459
Mouse Car12 Predicted Functions
Enables carbonate dehydratase activity. Predicted to be involved in chloride ion homeostasis and one-carbon metabolic process. Predicted to act upstream of or within carbon dioxide transport and regulation of pH. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis. Orthologous to human CA12 (carbonic anhydrase 12).
Rat Ca12 Target Information
- Target Symbol: Ca12, carbonic anhydrase 12
- Alias:
- Car12
- carbonic anyhydrase 12
- LOC363085
- membrane-bound carbonic anhydrase 12
- NCBI_Gene: 363085
- UniProtKB: A2IBE2
Rat Ca12 Predicted Functions
Predicted to enable carbonate dehydratase activity. Predicted to be involved in chloride ion homeostasis and one-carbon metabolic process. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis. Orthologous to human CA12 (carbonic anhydrase 12).
