Interleukin 1 (IL-1) is a 17 kDa extracellular polypeptide that is divided into two proteins, IL-1α and IL-1β.IL-1β is the activated form of the protein precursor secreted by activated macrophages and produced by hydrolysis of caspase1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response and is involved in many cellular activities including cell proliferation, differentiation and apoptosis.IL-1 is an important family of proteins that are derived from biologically activated monocytes and are involved in inflammatory responses and immune responses.Elevated expression of IL-1β produces a wide variety of different autoinflammatory syndromes, the most notable of which is a single-gene condition known as CAPS that is caused by mutations in NLRP3, the inflammasome receptor that triggers IL-1β processing. This kit is used to detect the mature and uncleaved precursor forms of human IL-1&beta.