HGNC ID: 5992
Target Abstract:
Interleukin 1 (IL-1) is a 17 kDa extracellular polypeptide that is divided into two proteins, IL-1α and IL-1β.IL-1β is the activated form of the protein precursor secreted by activated macrophages and produced by hydrolysis of caspase1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response and is involved in many cellular activities including cell proliferation, differentiation and apoptosis.IL-1 is an important family of proteins that are derived from biologically activated monocytes and are involved in inflammatory responses and immune responses.Elevated expression of IL-1β produces a wide variety of different autoinflammatory syndromes, the most notable of which is a single-gene condition known as CAPS that is caused by mutations in NLRP3, the inflammasome receptor that triggers IL-1β processing. This kit is used to detect the mature and uncleaved precursor forms of human IL-1&beta.
IL1B Target Infomation Overview
- Target Symbol: IL1B, interleukin 1 beta
- Gene Groups: Interleukins
- Alias: IL1F2; IL-1B; IL1-BETA
IL1B, interleukin 1 beta Target Infomation by Species
- Human
- Mouse
- Rat
Human IL1B Target Information
- Target Symbol: IL1B, interleukin 1 beta
- Alias:
- catabolin
- IL-1
- IL-1 beta
- IL1-BETA
- IL1beta
- IL1F2
- interleukin 1, beta
- interleukin 1beta
- interleukin-1 beta
- preinterleukin 1 beta
- pro-interleukin-1-beta
- NCBI_Gene: 3553
- UniProtKB: P01584
Human IL1B Predicted Functions
Enables cytokine activity; integrin binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of nitrogen compound metabolic process; and regulation of signal transduction. Acts upstream of or within cellular response to organic substance and cellular response to xenobiotic stimulus. Located in extracellular space. Implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); bronchial disease (multiple); lung disease (multiple); and nose disease (multiple).
Mouse Il1b Target Information
- Target Symbol: Il1b, interleukin 1 beta
- Alias:
- IL-1B
- Il-1b
- IL-1beta
- NCBI_Gene: 16176
Mouse Il1b Predicted Functions
Enables cytokine activity. Involved in several processes, including negative regulation of cell communication; regulation of defense response; and regulation of lipid metabolic process. Acts upstream of or within several processes, including ectopic germ cell programmed cell death; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in extracellular space and secretory granule. Is expressed in several structures, including dorsal aorta; early conceptus; hemolymphoid system; integument; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Orthologous to human IL1B (interleukin 1 beta).
Rat Il1b Target Information
- Target Symbol: Il1b, interleukin 1 beta
- Alias:
- IL-1 beta
- IL-1F2
- interleukin-1 beta
- NCBI_Gene: 24494
Rat Il1b Predicted Functions
Enables cytokine activity. Involved in several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and regulation of neurogenesis. Located in extracellular space. Used to study several diseases, including artery disease (multiple); brain disease (multiple); glomerulonephritis (multiple); interstitial lung disease (multiple); and kidney failure (multiple). Biomarker of several diseases, including artery disease (multiple); auditory system disease (multiple); brain disease (multiple); kidney failure (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Orthologous to human IL1B (interleukin 1 beta).
