Target Abstract: Tropomyosin receptor kinase A (TrkA), also known as neurotrophic tyrosine kinase receptor type 1 (NTRK1), is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA mediates the multiple effects of nerve growth factor, which include neuronal differentiation and avoidance of programmed cell death. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain with anhidrosis, self-mutilating behavior, mental retardation and cancer. TrkA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in TrkA are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma.
NTRK1 Target Infomation Overview
- Target Symbol: NTRK1, neurotrophic receptor tyrosine kinase 1
- Gene Groups: Receptor tyrosine kinases; Immunoglobulin like domain containing
- Alias: TRK; TRKA; MTC
- Alias Names: neurotrophic tyrosine kinase, receptor, type 1; high affinity nerve growth factor receptor; tropomyosin receptor kinase A
NTRK1, neurotrophic receptor tyrosine kinase 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human NTRK1 Target Information
- Target Symbol: NTRK1, neurotrophic receptor tyrosine kinase 1
- Alias:
- DKFZp781I14186
- gp140trk
- high affinity nerve growth factor receptor
- MTC
- neurotrophic tyrosine kinase, receptor, type 1
- Oncogene TRK
- p140-TrkA
- TRK
- trk precursor
- Trk-A
- TRK1
- TRK1-transforming tyrosine kinase protein
- TRKA
- tropomyosin receptor kinase A
- tropomyosin-related kinase A
- tyrosine kinase receptor A
- NCBI_Gene: 4914
- UniProtKB: P04629
Human NTRK1 Predicted Functions
Enables several functions, including nerve growth factor binding activity; nerve growth factor receptor activity; and protein homodimerization activity. Involved in several processes, including neurotrophin signaling pathway; positive regulation of intracellular signal transduction; and protein phosphorylation. Acts upstream of or within neuron projection development and peptidyl-tyrosine autophosphorylation. Located in plasma membrane. Part of receptor complex. Implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Biomarker of several diseases, including Hirschsprung's disease; lung disease (multiple); neuroblastoma; obstructive sleep apnea; and rhinitis.
Mouse Ntrk1 Target Information
- Target Symbol: Ntrk1, neurotrophic tyrosine kinase, receptor, type 1
- Alias:
- C80751
- expressed sequence C80751
- Tkr
- Trk
- TrkA
- tyrosine kinase receptor proto-oncogene
- NCBI_Gene: 18211
Mouse Ntrk1 Predicted Functions
Predicted to enable several functions, including GPI-linked ephrin receptor activity; nerve growth factor binding activity; and nerve growth factor receptor activity. Involved in circadian rhythm; negative regulation of neuron apoptotic process; and nervous system development. Acts upstream of or within several processes, including behavioral response to formalin induced pain; nerve growth factor signaling pathway; and nervous system development. Located in axon; cell surface; and endosome. Part of protein-containing complex. Is expressed in several structures, including branchial arch; nervous system; reproductive system; sensory organ; and trunk. Used to study hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1).
Rat Ntrk1 Target Information
- Target Symbol: Ntrk1, neurotrophic receptor tyrosine kinase 1
- Alias:
- high affinity nerve growth factor receptor
- neurotrophic tyrosine kinase, receptor, type 1
- p140-TrkA
- slow nerve growth factor receptor
- Trk
- trk precursor
- trk-A
- TrkA neurotrophin receptor
- trkA proto-oncogene receptor
- tropomyosin-related kinase A
- NCBI_Gene: 59109
Rat Ntrk1 Predicted Functions
Enables several functions, including GPI-linked ephrin receptor activity; nerve growth factor binding activity; and neurotrophin p75 receptor binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and positive regulation of cell communication. Acts upstream of or within cellular response to growth factor stimulus and protein autophosphorylation. Located in several cellular components, including cell surface; endosome; and neuronal cell body. Part of protein-containing complex. Used to study Parkinsonism; glaucoma; and myofascial pain syndrome. Biomarker of several diseases, including colitis; diabetic neuropathy; glaucoma; periodontitis; and retinal detachment. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1).