HGNC ID: 7159
Target Abstract:
Matrix metalloproteinases (MMPs) are calcium-dependent zinc-containing proteases, of which 26 members (MMP-1 to MMP-26) have been identified. MMPs are involved in the degradation of extracellular matrix in normal physiological processes (such as embryonic development, reproduction, tissue remodeling) and pathological processes (such as arthritis and metastasis). MMP-13, also known as collagenase 3, is encoded by the MMP13 gene in humans. Like most MMPs, it is secreted as an inactive precursor. MMP-13 is activated once the propeptide domain is cleaved, and the activated enzyme consists of the catalytic domain and the heme-like domain PDB: 1PEX. During embryonic development, MMP-13 is expressed in bone and is essential for the reorganization of collagen matrix during bone mineralization. In pathological conditions, such as tumors, rheumatoid arthritis, and osteoarthritis, MMP-13 is highly overexpressed.
MMP13 Target Infomation Overview
- Target Symbol: MMP13, matrix metallopeptidase 13
- Gene Groups: Receptor ligands; M10 matrix metallopeptidases
- Alias: CLG3
- Alias Names: collagenase 3; matrix metalloproteinase 13 (collagenase 3)
MMP13, matrix metallopeptidase 13 Target Infomation by Species
- Human
- Mouse
- Rat
Human MMP13 Target Information
- Target Symbol: MMP13, matrix metallopeptidase 13
- Alias:
- CLG3
- collagenase 3
- MANDP1
- matrix metallopeptidase 13 (collagenase 3)
- matrix metalloproteinase 13 (collagenase 3)
- MDST
- MMP-13
- NCBI_Gene: 4322
- UniProtKB: P45452
Human MMP13 Predicted Functions
Enables collagen binding activity; metal ion binding activity; and metalloendopeptidase activity. Involved in bone morphogenesis; collagen catabolic process; and extracellular matrix disassembly. Predicted to be located in extracellular space. Predicted to be part of collagen trimer. Implicated in anodontia; artery disease (multiple); osteoarthritis; ovarian carcinoma; and spondyloepimetaphyseal dysplasia, Missouri type. Biomarker of invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer.
Mouse Mmp13 Target Information
- Target Symbol: Mmp13, matrix metallopeptidase 13
- Alias:
- Clg
- collagenase-1
- Collagenase-3
- collagenase, fibroblast
- interstitial collagenase
- matrix metalloproteinase 1
- MMP-13
- Mmp1
- NCBI_Gene: 17386
Mouse Mmp13 Predicted Functions
Enables metalloendopeptidase activity. Involved in several processes, including bone mineralization; endochondral ossification; and extracellular matrix disassembly. Acts upstream of or within cellular protein metabolic process; collagen catabolic process; and growth plate cartilage development. Predicted to be located in several cellular components, including Golgi apparatus; intercellular canaliculus; and lysosome. Is expressed in several structures, including connective tissue; inner ear; jaw; limb mesenchyme; and skeletal system. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); osteoarthritis; ovarian carcinoma; and spondyloepimetaphyseal dysplasia, Missouri type. Orthologous to human MMP13 (matrix metallopeptidase 13).
Rat Mmp13 Target Information
- Target Symbol: Mmp13, matrix metallopeptidase 13
- Alias:
- collagenase 3
- collagenase-3
- interstitial collagenase
- matrix metalloproteinase 13
- matrix metalloproteinase-13
- MMP-13
- UMRCASE
- NCBI_Gene: 171052
Rat Mmp13 Predicted Functions
Enables several functions, including fibronectin binding activity; low-density lipoprotein particle receptor binding activity; and metal ion binding activity. Involved in several processes, including animal organ development; embryonic hindlimb morphogenesis; and estrous cycle. Located in several cellular components, including Golgi apparatus; intercellular canaliculus; and lysosome. Used to study brain ischemia; degenerative disc disease; and myocardial infarction. Biomarker of several diseases, including degenerative disc disease; gastric ulcer; liver cirrhosis (multiple); meningococcal meningitis; and silicosis. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); osteoarthritis; ovarian carcinoma; and spondyloepimetaphyseal dysplasia, Missouri type. Orthologous to human MMP13 (matrix metallopeptidase 13).
