HGNC ID: 3176
Target Abstract:
Endothelin-1 (ET-1) is a polypeptide composed of 21 amino acid residues and is a pleiotropic component. It was originally a pre peptide of 212 amino acids. Vascular endothelial cells are a rich source of ET-1. The expression of ET-1 in endothelial cells is influenced by various factors, including mechanical stimulation, multiple hormones, and pro-inflammatory cytokines. Endothelin is first identified as an endothelin derived relaxing factor, and then as an endothelin derived contractile factor. ET-1 stimulates myocardial contraction and cell growth, regulates the release of vasoactive substances, and stimulates smooth muscle cell mitosis. It also serves as a growth promoting factor for endothelial cells and is regulated by hypothalamic and pituitary cells for secretion. ET-1 may control the inflammatory response by promoting the adhesion and migration of neutrophils and stimulating the production of pro-inflammatory cytokines.
EDN1 Target Infomation Overview
- Target Symbol: EDN1, endothelin 1
- Gene Groups: Endothelins
- Alias: ET1
EDN1, endothelin 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human EDN1 Target Information
- Target Symbol: EDN1, endothelin 1
- Alias:
- ARCND3
- endothelin-1
- ET1
- HDLCQ7
- PPET1
- preproendothelin-1
- QME
- NCBI_Gene: 1906
- UniProtKB: P05305
Human EDN1 Predicted Functions
Enables signaling receptor binding activity. Involved in several processes, including intracellular signal transduction; regulation of macromolecule biosynthetic process; and vascular associated smooth muscle contraction. Located in cytoplasm and extracellular space. Implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); glaucoma (multiple); lung disease (multiple); and retinal disease (multiple).
Mouse Edn1 Target Information
- Target Symbol: Edn1, endothelin 1
- Alias:
- ET-1
- NCBI_Gene: 13614
Mouse Edn1 Predicted Functions
Enables endothelin A receptor binding activity. Involved in several processes, including cellular response to gonadotropin stimulus; circulatory system development; and neuron differentiation. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; animal organ development; and rhythmic excitation. Located in extracellular space. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; gut; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); lung disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1).
Rat Edn1 Target Information
- Target Symbol: Edn1, endothelin 1
- Alias:
- dickkopf 1 homolog
- dickkopf 1 homolog (Xenopus laevis)
- dickkopf homolog 1
- dickkopf homolog 1 (Xenopus laevis)
- dickkopf-like protein 1
- dickkopf-related protein 1
- LOC293897
- NEWGENE_1307313
- NCBI_Gene: 24323
- UniProtKB: P22388
Rat Edn1 Predicted Functions
Predicted to enable co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in negative regulation of ossification and positive regulation of neuron death. Located in extracellular space. Used to study visual epilepsy. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1).
