HGNC ID: 10639
Target Abstract:
The chemokine CXC ligand 13 (CXCL13), also known as B-lymphocyte chemokine (BLC) or BCA-1, is expressed at high levels in human liver, spleen, lymph nodes and intestine. It selectively chemotaxis B cells belonging to the B-1 and B-2 subpopulations and exhibits its function by interacting with the chemokine receptor CXCR5.CXCL13, together with its receptor CXCR5, regulates the B-cell architecture in lymphoid follicles. In T cells, the expression of CXCL13 is thought to reflect the origin of T cell, especially follicular helper T cell (Tfh) germinal centers. Thus CXCL13 expression in T-cell lymphomas, such as angioimmunoblastic T-cell lymphoma, is thought to reflect the origin of the tumor T-cell germinal center.
CXCL13 Target Infomation Overview
- Target Symbol: CXCL13, C-X-C motif chemokine ligand 13
- Gene Groups: Chemokine ligands
- Alias: BLC; BCA-1; BLR1L; ANGIE; ANGIE2
- Previous Names: SCYB13
- Alias Names: B-cell chemoattractant; small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); chemokine (C-X-C motif) ligand 13
CXCL13, C-X-C motif chemokine ligand 13 Target Infomation by Species
- Human
- Mouse
- Rat
Human CXCL13 Target Information
- Target Symbol: CXCL13, C-X-C motif chemokine ligand 13
- Alias:
- ANGIE
- ANGIE2
- b cell-attracting chemokine 1
- b lymphocyte chemoattractant
- B-cell chemoattractant
- B-cell-attracting chemokine 1
- B-cell-homing chemokine (ligand for Burkitt’s lymphoma receptor-1)
- B-lymphocyte chemoattractant
- BCA-1
- BCA1
- BLC
- BLR1L
- C-X-C motif chemokine 13
- chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
- CXC chemokine BLC
- SCYB13
- small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)
- small-inducible cytokine B13
- NCBI_Gene: 10563
- UniProtKB: O43927
Human CXCL13 Predicted Functions
Enables chemokine receptor binding activity; fibroblast growth factor binding activity; and heparin binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cell chemotaxis; and regulation of chemotaxis. Located in extracellular region.
Mouse Cxcl13 Target Information
- Target Symbol: Cxcl13, chemokine (C-X-C motif) ligand 13
- Alias:
- 4631412M08Rik
- ANGIE2
- BCA-1
- BLC
- RIKEN cDNA 4631412M08 gene
- Scyb13
- small inducible cytokine subfamily B (Cys-X-Cys), member 13
- NCBI_Gene: 55985
Mouse Cxcl13 Predicted Functions
Enables CXCR5 chemokine receptor binding activity and chemokine activity. Involved in several processes, including B cell chemotaxis across high endothelial venule; activation of GTPase activity; and lymph node development. Located in extracellular space. Is expressed in Peyer’s patch; aorta; central nervous system; and retina. Orthologous to human CXCL13 (C-X-C motif chemokine ligand 13).
Rat Cxcl13 Target Information
- Target Symbol: Cxcl13, C-X-C motif chemokine ligand 13
- Alias:
- C-X-C motif chemokine 13
- chemokine (C-X-C motif) ligand 13
- LOC498335
- similar to Small inducible cytokine B13 precursor (CXCL13) (B lymphocyte chemoattractant) (CXC chemokine BLC)
- NCBI_Gene: 498335
Rat Cxcl13 Predicted Functions
Predicted to enable chemokine receptor binding activity; fibroblast growth factor binding activity; and heparin binding activity. Predicted to be involved in several processes, including cell chemotaxis; regulation of chemotaxis; and response to bacterium. Predicted to act upstream of or within lymph node development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CXCL13 (C-X-C motif chemokine ligand 13).
