HGNC ID: 5966

Target Abstract:

Interleukin 11 (IL-11) is a multifunctional cytokine that was isolated from bone marrow mesenchymal stem cells as early as 1990 and is a member of the IL-6 family of cytokines that can be distinguished by their use of the co-receptor gp130. It is a member of the IL-6 family of cytokines, which can be distinguished by their use of the co-receptor gp130. IL-11 plays an important regulatory role in hematopoietic regulation, particularly in stimulating the maturation of megakaryocytes. IL-11 has been shown to ameliorate chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate the antigen-antibody response, and participate in the regulation of osteoblast proliferation and differentiation.IL-11 induces bone resorption, stimulates the growth of certain lymphocytes, and, in a mouse model, stimulates an increase in the cortical thickness and strength of the long bones. As a signaling molecule, IL-11 has a variety of functions, including placentation and some degree of metamorphosis, and has a role in the implantation of the blastocyst into the endometrium.IL-11 was synthesized using recombinant DNA technology and is commercially known as Oprimum interleukin and is used to prevent severe thrombocytopenia in cancer patients.

IL11 Target Infomation Overview

• Target Symbol: IL11, interleukin 11
• Gene Groups: Interleukins; Interleukin 6 type cytokine family
• Alias: IL-11; AGIF
• Alias Names: adipogenesis inhibitory factor; oprelvekin

IL11, interleukin 11 Target Infomation by Species