HGNC ID: 8548
Target Abstract:
Protein disulfide isomerase, also known as proline 4-hydroxylase β The subunit (P4HB), cellular thyroid hormone-binding protein (p55), and glutathione-insulin transhydrogenase are peripheral membrane proteins belonging to the protein disulfide isomerase family. It contains two thioredoxin domains that catalyze the formation, breaking and rearrangement of disulfide bonds. P4HB was located near the CD4 rich area on the surface of lymphocytes. In the melanomsome component, P4HB reduces and activates the fusion properties of the HIV-1 gp120 surface protein, thereby allowing HIV-1 to enter the cell. P4HB acts as a chaperone, inhibiting the aggregation of misfolded proteins. P4HB may be involved with other molecular chaperones in the structural modification of TG precursors in hormone biosynthesis.
P4HB Target Infomation Overview
- Target Symbol: P4HB, prolyl 4-hydroxylase subunit beta
- Gene Groups: Protein disulfide isomerases
- Alias: PDIA1; PROHB; DSI; GIT; PDI; PO4HB; P4Hbeta
- Previous Names: PO4DB; ERBA2L
- Alias Names: protein disulfide isomerase-associated 1; protein disulfide isomerase family A, member 1; collagen prolyl 4-hydroxylase beta; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55); procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1); procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide; prolyl 4-hydroxylase, beta polypeptide
P4HB, prolyl 4-hydroxylase subunit beta Target Infomation by Species
- Human
- Mouse
- Rat
Human P4HB Target Information
- Target Symbol: P4HB, prolyl 4-hydroxylase subunit beta
- Alias:
- cellular thyroid hormone-binding protein
- CLCRP1
- collagen prolyl 4-hydroxylase beta
- DSI
- ERBA2L
- GIT
- glutathione-insulin transhydrogenase
- P4Hbeta
- p55
- PDI
- PDIA1
- PHDB
- PO4DB
- PO4HB
- procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
- PROHB
- prolyl 4-hydroxylase, beta polypeptide
- protein disulfide isomerase family A, member 1
- protein disulfide isomerase-associated 1
- protein disulfide isomerase/oxidoreductase
- protein disulfide-isomerase
- protocollagen hydroxylase
- testicular secretory protein Li 32
- thyroid hormone-binding protein p55
- v-erb-a avian erythroblastic leukemia viral oncogene homolog 2-like
- NCBI_Gene: 5034
- UniProtKB: P07237
Human P4HB Predicted Functions
Enables several functions, including oxidoreductase activity, acting on a sulfur group of donors; protein disulfide isomerase activity; and protein heterodimerization activity. Contributes to procollagen-proline 4-dioxygenase activity. Involved in several processes, including positive regulation of substrate adhesion-dependent cell spreading; positive regulation of viral entry into host cell; and protein folding in endoplasmic reticulum. Acts upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Located in several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; external side of plasma membrane; and lamellipodium. Part of procollagen-proline 4-dioxygenase complex. Implicated in Cole-Carpenter syndrome.
Mouse P4hb Target Information
- Target Symbol: P4hb, prolyl 4-hydroxylase, beta polypeptide
- Alias:
- ERp59
- PDI
- Pdia1
- protein disulfide isomerase
- Thbp
- thyroid hormone binding protein
- NCBI_Gene: 18453
Mouse P4hb Predicted Functions
Enables integrin binding activity. Acts upstream of or within cellular response to interleukin-7. Located in endoplasmic reticulum and external side of plasma membrane. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta).
Rat P4hb Target Information
- Target Symbol: P4hb, prolyl 4-hydroxylase subunit beta
- Alias:
- cellular thyroid hormone-binding protein
- PDI
- PDIR
- prolyl 4-hydroxylase, beta polypeptide
- protein disulfide isomerase
- protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide)
- protein disulfide-isomerase
- NCBI_Gene: 25506
- UniProtKB: P04785
Rat P4hb Predicted Functions
Enables enzyme binding activity and protein disulfide isomerase activity. Predicted to be involved in several processes, including positive regulation of substrate adhesion-dependent cell spreading; positive regulation of viral entry into host cell; and protein folding in endoplasmic reticulum. Predicted to act upstream of or within cellular response to interleukin-7 and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum-Golgi intermediate compartment; and lamellipodium. Predicted to be part of endoplasmic reticulum chaperone complex and procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum and external side of plasma membrane. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta).
