HGNC ID: 5344
Target Abstract:
Intercellular adhesion molecule 1 (ICAM-1), also known as CD54, is a nearly ubiquitous transmembrane glycoprotein that is normally expressed in endothelial and immune cells and has a key role in leukocyte migration and activation. It binds to CD11a/CD18 or CD11b/CD18 type integrins and is also utilized by rhinoviruses as a receptor. Soluble intercellular adhesion molecule 1 (sICAM-1) promotes angiogenesis and can be used as an indicator of activated or damaged vascular endothelial cells. It also acts as a transmembrane ICAM-1 inhibitor, mediating activities such as monocyte adhesion to activated endothelial cells and sensitivity of tumor cells to NK cell-mediated lysis. Monitoring serum levels of sICAM-1 expression may provide a more detailed perspective on a variety of pathologies such as cardiovascular disease, type II diabetes, organ transplantation disorders, oxidative stress, abdominal cellulite, hypertension, liver disease, and certain malignancies.
ICAM1 Target Infomation Overview
- Target Symbol: ICAM1, intercellular adhesion molecule 1
- Gene Groups: CD molecules; Receptor ligands; Immunoglobulin like domain containing; Ig-like cell adhesion molecule family
- Alias: BB2; CD54
- Alias Names: human rhinovirus receptor
ICAM1, intercellular adhesion molecule 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human ICAM1 Target Information
- Target Symbol: ICAM1, intercellular adhesion molecule 1
- Alias:
- BB2
- CD54
- cell surface glycoprotein P3.58
- human rhinovirus receptor
- ICAM-1
- intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
- major group rhinovirus receptor
- P3.58
- NCBI_Gene: 3383
- UniProtKB: P05362
Human ICAM1 Predicted Functions
Enables integrin binding activity. Involved in several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; cellular response to amyloid-beta; and negative regulation of apoptotic process. Located in extracellular exosome. Implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetes mellitus (multiple); hematologic cancer (multiple); and lung disease (multiple).
Mouse Icam1 Target Information
- Target Symbol: Icam1, intercellular adhesion molecule 1
- Alias:
- CD54
- Icam-1
- Ly-47
- lymphocyte antigen 47
- MALA-2
- MGC:6195
- NCBI_Gene: 15894
Mouse Icam1 Predicted Functions
Predicted to enable integrin binding activity. Acts upstream of or within several processes, including T cell antigen processing and presentation; cellular response to glucose stimulus; and cellular response to leukemia inhibitory factor. Located in external side of plasma membrane and immunological synapse. Colocalizes with membrane raft. Is expressed in several structures, including cardiovascular system; liver vasculature; lung; skin; and thymus primordium. Used to study malaria. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; inflammatory bowel disease (multiple); liver cirrhosis; and uveitis (multiple). Orthologous to human ICAM1 (intercellular adhesion molecule 1).
Rat Icam1 Target Information
- Target Symbol: Icam1, intercellular adhesion molecule 1
- Alias:
- CD54
- ICAM
- ICAM-1
- NCBI_Gene: 25464
- UniProtKB: Q00238
Rat Icam1 Predicted Functions
Enables integrin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and gonad development. Located in cell surface; extracellular space; and plasma membrane. Used to study diabetic angiopathy; mesenteric vascular occlusion; nephritis; pre-eclampsia; and uveitis. Biomarker of several diseases, including cerebrovascular disease (multiple); colitis (multiple); kidney failure (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Orthologous to human ICAM1 (intercellular adhesion molecule 1).
