Target Abstract: Gas6 (Growth Arrest Specific 6) is a secreted protein that contains an extensively gamma-carboxylated N-terminal Gla domain and is dependent upon vitamin K for activity. Gas6 signals through the receptors Axl, Dtk/Tyro3, and Mer and is inhibited by shed soluble forms of Axl and Mer. Gas6 protects cells from stress-induced apoptosis and promotes phagocytosis of apoptotic cell debris, promotes platelet activation but inhibits inflammatory cytokine production, and inhibits VEGF-induced angiogenesis, and regulates tumor cell invasiveness.
GAS6 Target Infomation Overview
- Target Symbol: GAS6, growth arrest specific 6
- Gene Groups: Gla domain containing
- Alias: AXSF; FLJ34709; DKFZp666G247, AXLLG
- Alias Names: AXL receptor tyrosine kinase ligand; AXL stimulatory factor
GAS6, growth arrest specific 6 Target Infomation by Species
- Human
- Mouse
- Rat
人 Human GAS6 Target Information
- Target Symbol: GAS6, growth arrest specific 6
- Alias:
- AXL receptor tyrosine kinase ligand
- AXL stimulatory factor
- AXLLG
- AXSF
- DKFZp666G247
- FLJ34709
- GAS-6
- growth arrest-specific 6
- growth arrest-specific protein 6
- NCBI_Gene: 2621
- UniProtKB: Q14393
Human GAS6 Predicted Functions
Enables several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; phosphatidylserine binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of apoptotic process; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within positive regulation of ERK1 and ERK2 cascade and positive regulation of fibroblast proliferation. Located in cytoplasm and extracellular space.
Mouse Gas6 Target Information
- Target Symbol: Gas6, growth arrest specific 6
- Alias:
- GAS 6
- Gas-6
- growth arrest-specific
- NCBI_Gene: 14456
Mouse Gas6 Predicted Functions
Enables receptor ligand activity. Involved in negative regulation of apoptotic process. Acts upstream of or within several processes, including blood coagulation; negative regulation of apoptotic process; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and limb. Orthologous to human GAS6 (growth arrest specific 6).Rat Gas6 Target Information
- Target Symbol: Gas6, growth arrest specific 6
- Alias:
- AXL receptor tyrosine kinase ligand
- GAS-6
- GPF
- growth arrest-specific protein 6
- growth-potentiating factor
- NCBI_Gene: 58935
