HGNC ID: 10619
Target Abstract:
Chemokine ligand 20 (CCL20), also known as macrophage inflammatory protein 3α (MIP-3α), is a small molecular weight cytokine of the CC chemokine family.CCL20 has a strong chemotactic effect on lymphocytes and a weak chemotactic effect on neutrophils. Monocytes, macrophages, microglia, astrocytes, mast cells, keratinocytes, intestinal epithelial cells, osteoblasts, fibroblasts, endothelial cells, and bronchial epithelial cells express CCL20.CCL20 chemotaxis of lymphocytes and dendritic cells to epithelial cells surrounding mucosal lymphoid tissues and thus participates in the formation and functioning of mucosal lymphoid tissues.CCL20 CCL20 binds and activates the chemokine receptor CCR6 to act on target cells.CCL20 may play an important role in the pathogenesis of autoimmune diseases of the central nervous system.
CCL20 Target Infomation Overview
- Target Symbol: CCL20, C-C motif chemokine ligand 20
- Gene Groups: Chemokine ligands
- Alias: LARC; MIP-3a; exodus-1; ST38; CKb4
- Previous Names: SCYA20
- Alias Names: small inducible cytokine subfamily A (Cys-Cys), member 20; chemokine (C-C motif) ligand 20
CCL20, C-C motif chemokine ligand 20 Target Infomation by Species
- Human
- Mouse
- Rat
Human CCL20 Target Information
- Target Symbol: CCL20, C-C motif chemokine ligand 20
- Alias:
- beta chemokine exodus-1
- beta-chemokine exodus-1
- C-C motif chemokine 20
- CC chemokine LARC
- chemokine (C-C motif) ligand 20
- CKb4
- Exodus
- exodus-1
- LARC
- liver and activation-regulated chemokine
- macrophage inflammatory protein 3 alpha
- MIP-3-alpha
- MIP-3a
- MIP3A
- SCYA20
- small inducible cytokine subfamily A (Cys-Cys), member 20
- small-inducible cytokine A20
- ST38
- NCBI_Gene: 6364
- UniProtKB: P78556
Human CCL20 Predicted Functions
Enables CCR6 chemokine receptor binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; calcium-mediated signaling using intracellular calcium source; and cell chemotaxis. Acts upstream of or within positive regulation of T cell migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including IgA glomerulonephritis; Lyme disease; anogenital venereal wart; dermatitis (multiple); and skin papilloma.
Mouse Ccl20 Target Information
- Target Symbol: Ccl20, chemokine (C-C motif) ligand 20
- Alias:
- CKb4
- exodus-1
- MIP-3[a]
- MIP-3A
- MIP3A
- Scya20
- small inducible cytokine subfamily A20
- ST38
- NCBI_Gene: 20297
Mouse Ccl20 Predicted Functions
Enables CCR6 chemokine receptor binding activity and cytokine activity. Involved in chemotaxis and thymocyte migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CCL20 (C-C motif chemokine ligand 20).
Rat Ccl20 Target Information
- Target Symbol: Ccl20, C-C motif chemokine ligand 20
- Alias:
- beta chemokine exodus-1
- beta-chemokine exodus-1
- C-C motif chemokine 20
- CC chemokine LARC
- CC chemokine ST38
- chemokine (C-C motif) ligand 20
- liver and activation-regulated chemokine
- macrophage inflammatory protein 3 alpha
- MIP-3-alpha
- Scya20
- small inducible cytokine subfamily A20
- small-inducible cytokine A20
- ST38
- NCBI_Gene: 29538
- UniProtKB: P97884
Rat Ccl20 Predicted Functions
Enables chemokine activity. Involved in several processes, including cellular response to molecule of bacterial origin; positive regulation of macromolecule metabolic process; and wound healing. Located in extracellular space. Used to study transient cerebral ischemia. Biomarker of brain ischemia and ulcerative colitis. Orthologous to human CCL20 (C-C motif chemokine ligand 20).
