HGNC ID: 1074
Target Abstract:
Bone Morphogenetic Protein 7 (BMP-7), a member of the TGF-β superfamily, is expressed in the brain, kidneys, and bladder. It plays a critical role in the transformation of mesenchymal cells into bone and cartilage. BMP-7 induces the phosphorylation of SMAD1 and SMAD5, which, in turn, leads to the transcription of osteogenic genes. In many cell types, treatment with BMP-7 alone is sufficient to induce all genetic markers of osteoblast differentiation. BMP-7 shows potential for treating chronic kidney disease. In cases of infertility where follicle-stimulating hormone (FSH) treatment is ineffective, injection of BMP-7 may be considered as a therapeutic option. BMP-7 also holds potential for the treatment of human obesity.
BMP7 Target Infomation Overview
- Target Symbol: BMP7, bone morphogenetic protein 7
- Gene Groups: Bone morphogenetic proteins
- Alias: OP-1
- Alias Names: osteogenic protein 1
BMP7, bone morphogenetic protein 7 Target Infomation by Species
- Human
- Mouse
- Rat
Human BMP7 Target Information
- Target Symbol: BMP7, bone morphogenetic protein 7
- Alias:
- BMP-7
- OP-1
- osteogenic protein 1
- NCBI_Gene: 655
- UniProtKB: P18075
Human BMP7 Predicted Functions
Predicted to enable BMP receptor binding activity and cytokine activity. Involved in several processes, including regulation of gene expression; regulation of protein phosphorylation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within negative regulation of neuron differentiation and neuron projection morphogenesis. Located in extracellular space. Implicated in prostate cancer. Biomarker of breast cancer; ovarian carcinoma; prostate cancer; and renal cell carcinoma.
Mouse Bmp7 Target Information
- Target Symbol: Bmp7, bone morphogenetic protein 7
- Alias:
- OP1
- osteogenic protein 1
- NCBI_Gene: 12162
Mouse Bmp7 Predicted Functions
Predicted to enable BMP receptor binding activity; cytokine activity; and heparin binding activity. Involved in several processes, including allantois development; animal organ development; and chordate embryonic development. Acts upstream of or within several processes, including embryonic morphogenesis; morphogenesis of a branching epithelium; and regulation of morphogenesis of a branching structure. Located in extracellular space. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study obstructive sleep apnea and osteoarthritis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7).
Rat Bmp7 Target Information
- Target Symbol: Bmp7, bone morphogenetic protein 7
- Alias:
- BMP-7
- bone moorphogenic protein-7
- NCBI_Gene: 85272
- UniProtKB: G3V6W8
Rat Bmp7 Predicted Functions
Enables heparin binding activity. Involved in several processes, including response to estradiol; response to peptide hormone; and response to vitamin D. Located in collagen-containing extracellular matrix; extracellular space; and vesicle. Biomarker of acute kidney tubular necrosis; kidney disease; nephroblastoma; and pyelonephritis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7).
