HGNC ID: 8583
Target Abstract:
Serpin E1, also known as plasminogen activator inhibitor-1 (PAI-1), is a member of a superfamily of serine protease inhibitors that are produced primarily by the endothelium (cells lining the endothelium of blood vessels), but also secreted by other types of tissue such as adipose tissue. Serpin E1 is a major inhibitor of urokinase and tissue type plasminogen activators (uPA and tPA). The PA-fibrinolytic enzyme system is involved in a variety of physiological and pathological processes such as fibrinolysis, fibrosis, angiogenesis, wound healing, invasion and metastasis of tumor cells. For example, high levels of uPA and Serpin E1 are associated with poor prognosis in patients with breast cancer, and studies have confirmed that uPA and Serpin E1 are the most reliable biomarkers with grade 1 clinical value. In addition to breast cancer, Serpin E1 is also involved in many other diseases such as metabolic syndrome, asthma, major depressive disorder (MDD), and age-related diseases. The absence of Serpin E1 in the plasma will lead to abnormal bleeding, and high levels of Serpin E1 are associated with genetic susceptibility.
SERPINE1 Target Infomation Overview
- Target Symbol: SERPINE1, serpin family E member 1
- Gene Groups: Serpin peptidase inhibitors
- Alias: PAI
- Previous Names: PLANH1; PAI1
- Alias Names: plasminogen activator inhibitor, type I; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE1, serpin family E member 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human SERPINE1 Target Information
- Target Symbol: SERPINE1, serpin family E member 1
- Alias:
- endothelial plasminogen activator inhibitor
- PAI
- PAI-1
- PAI1
- PLANH1
- plasminogen activator inhibitor 1
- serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
- serpin E1
- serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
- NCBI_Gene: 5054
- UniProtKB: P05121
Human SERPINE1 Predicted Functions
Enables protease binding activity; serine-type endopeptidase inhibitor activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of proteolysis; regulation of angiogenesis; and response to bacterium. Located in collagen-containing extracellular matrix and extracellular exosome. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); lung disease (multiple); and sleep apnea (multiple).
Mouse Serpine1 Target Information
- Target Symbol: Serpine1, serine (or cysteine) peptidase inhibitor, clade E, member 1
- Alias:
- PAI-1
- PAI1
- Planh1
- plasminogen activator inhibitor, type I
- NCBI_Gene: 18787
Mouse Serpine1 Predicted Functions
Enables serine-type endopeptidase inhibitor activity. Involved in defense response to Gram-negative bacterium; negative regulation of plasminogen activation; and regulation of angiogenesis. Acts upstream of or within several processes, including cellular response to transforming growth factor beta stimulus; placenta development; and regulation of angiogenesis. Located in extracellular space. Is expressed in several structures, including aorta; extraembryonic component; liver; oocyte; and placenta. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1).
Rat Serpine1 Target Information
- Target Symbol: Serpine1, serpin family E member 1
- Alias:
- endothelial plasminogen activator inhibitor
- PAI
- PAI-1
- Pai1
- PAI1A
- Pai1aa
- Planh
- Plasminogen activator inhibitor
- plasminogen activator inhibitor 1
- RATPAI1A
- serine (or cysteine) peptidase inhibitor, clade E, member 1
- serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1
- serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
- serine (or cysteine) proteinase inhibitor, clade E, member 1
- serine (or cysteine) proteinase inhibitor, member 1
- serpin E1
- serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
- NCBI_Gene: 24617
Rat Serpine1 Predicted Functions
Enables protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and cellular response to organonitrogen compound. Located in chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal disease; and renal fibrosis. Biomarker of several diseases, including acute necrotizing pancreatitis; glomerulosclerosis (multiple); lung disease (multiple); middle cerebral artery infarction; and muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1).
