HGNC ID: 11936
Target Abstract:
Fas ligand, also known as TNFSF6, FasL or CD95L, is a member of the tumor necrosis factor (TNF) family. It is a homotrimeric type II transmembrane protein expressed on cytotoxic T lymphocytes. Cleavage of membrane-bound FasL by the ecto-matrix metalloproteinase MMP-7 at a conserved cleavage site generates soluble Fas ligand.Fas ligand/receptor interactions play an important role in the regulation of the immune system and cancer progression. It generates signals through the trimerization of FasR, and this trimerization usually leads to apoptosis or cell death. Apoptosis induced by Fas-Fas ligand binding plays a crucial role in the regulation of the immune system, which functions in T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, and tumor counteraction. Defective Fas-mediated apoptosis can lead to tumorigenesis and drug resistance in existing tumors.Mutations in the Fas gene are associated with autoimmune lymphoproliferative syndrome (ALPS).
FASLG Target Infomation Overview
- Target Symbol: FASLG, Fas ligand
- Gene Groups: CD molecules; Tumor necrosis factor superfamily; Death inducing signaling complex
- Alias: FasL; CD178
- Previous Names: APT1LG1; TNFSF6
- Alias Names: tumor necrosis factor (ligand) superfamily, member 6; Fas ligand (TNF superfamily, member 6)
FASLG, Fas ligand Target Infomation by Species
- Human
- Mouse
- Rat
Human FASLG Target Information
- Target Symbol: FASLG, Fas ligand
- Alias:
- ALPS1B
- apoptosis (APO-1) antigen ligand 1
- apoptosis antigen ligand
- APT1LG1
- APTL
- CD178
- CD95 ligand
- CD95-L
- CD95L
- fas antigen ligand
- Fas ligand (TNF superfamily, member 6)
- FASL
- mutant tumor necrosis factor family member 6
- TNFSF6
- TNLG1A
- tumor necrosis factor (ligand) superfamily, member 6
- tumor necrosis factor ligand 1A
- tumor necrosis factor ligand superfamily member 6
- NCBI_Gene: 356
- UniProtKB: P48023
Human FASLG Predicted Functions
Predicted to enable signaling receptor binding activity. Involved in several processes, including necroptotic signaling pathway; positive regulation of endothelial cell apoptotic process; and positive regulation of phosphatidylserine exposure on apoptotic cell surface. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of apoptotic process; and release of sequestered calcium ion into cytosol by endoplasmic reticulum. Located in extracellular exosome; nucleus; and plasma membrane. Implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; pancreatic cancer (multiple); pre-eclampsia (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including bone marrow cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; clonorchiasis; and neurodegenerative disease (multiple).
Mouse Fasl Target Information
- Target Symbol: Fasl, Fas ligand (TNF superfamily, member 6)
- Alias:
- APT1LG1
- CD178
- CD95L
- Fas antigen ligand
- Fas-L
- generalized lymphoproliferative disease
- gld
- Tnfsf6
- tumor necrosis factor (ligand) superfamily, member 6
- NCBI_Gene: 14103
Mouse Fasl Predicted Functions
Predicted to enable death receptor binding activity and tumor necrosis factor receptor binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and trophectoderm. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand).
Rat Faslg Target Information
- Target Symbol: Faslg, Fas ligand
- Alias:
- apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand)
- Apt1Lg1
- CD95 ligand
- CD95-L
- CD95L protein
- Fas antigen ligand
- Fas ligand (TNF superfamily, member 6)
- Fasl
- Tnfsf6
- Tnlg1a
- Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
- tumor necrosis factor (ligand) superfamily, member 6
- Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
- tumor necrosis factor ligand 1a
- tumor necrosis factor ligand superfamily member 6
- NCBI_Gene: 25385
Rat Faslg Predicted Functions
Enables death receptor binding activity and tumor necrosis factor receptor binding activity. Involved in several processes, including cellular ion homeostasis; cellular response to interferon-gamma; and extrinsic apoptotic signaling pathway via death domain receptors. Located in caveola; cytoplasmic vesicle; and perinuclear region of cytoplasm. Used to study brain glioma; substance-related disorder; and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); chronic obstructive pulmonary disease; gastric ulcer; liver disease (multiple); and ulcerative colitis. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand).
