Human TREM2 ELISA Kit

$350.00$450.00

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TARGETSTREM2
SPECIESHuman
Sample TypeSerum, plasma, cell culture supernatant, and other biological samples
Sample Volume50 μL 1×Assay Buffer and 50 μL sample
Sensitivity15.93 pg/mL
Range0.16 ng/mL – 10 ng/mL
Assay Time3.5 h
Recovery72% – 122%
Average Recovery0.88
Sample TypeSerum, plasma, cell culture supernatant, and other biological samples
Sample Volume50 μL 1×Assay Buffer and 50 μL sample
Sensitivity15.93 pg/mL
Range0.16 ng/mL – 10 ng/mL
Assay Time3.5 h
Recovery72% – 122%
Average Recovery0.88
Intra Precision2.6% – 6.0%
Inter-Precision3.5% – 7.9%
PlatformELISA
PlateDetachable 96-well plate
Size96T/48T
StorageIf the reagent kit is unopened, it should be stored at 4℃. However, if it has been opened, the standard solution should be stored at -20℃, while the other components should be stored at 4℃.
Delivery4℃ blue ice transportation
Components96-well polystyrene enzyme-linked immunosorbent assay (ELISA) plate coated with anti-TREM2 monoclonal antibody
Human TREM2 freeze-dried standard
TREM2 detect Antibody
Standard Diluent
Assay Buffer(10×)
Substrate TMB
Stop Solution
Washing Buffer(20×)
Sealing Film
Assay PrincipleThis kit utilizes the double antibody sandwich enzyme-linked immunosorbent assay (ELISA) detection technique.Specific anti-human TREM2 antibodies are precoated on a high-affinity ELISA plate. Standard samples, test samples, and the detection antibody labeled with horseradish peroxidase are added to the wells of the ELISA plate. After incubation, TREM2 present in the samples binds to the solid-phase antibody and the detection antibody. After washing, a colorimetric substrate, TMB, is added and the plate is incubated in the dark for color development. The intensity of the color reaction is directly proportional to the concentration of TREM2 in the samples.A stop solution is added to terminate the reaction, and the absorbance value is measured at a wavelength of 450 nm (with a reference wavelength range of 570-630 nm).

 

Targets

TREM2

TREM2 Target Infomation Overview

  • Target Symbol: TREM2, triggering receptor expressed on myeloid cells 2
  • Gene Groups: V-set domain containing
  • Alias: TREM-2; Trem2a; Trem2b; Trem2c
  • Alias Names: triggering receptor expressed on myeloid cells 2a

TREM2, triggering receptor expressed on myeloid cells 2 Target Infomation by Species

HumanMouseRat

Human TREM2 Target Information

  • Target Symbol: TREM2, triggering receptor expressed on myeloid cells 2
  • Alias:
    • PLOSL2
    • TREM-2
    • Trem2a
    • Trem2b
    • Trem2c
    • triggering receptor expressed on monocytes 2
    • triggering receptor expressed on myeloid cells 2a
  • NCBI_Gene: 54209
  • UniProtKB: Q9NZC2

Human TREM2 Predicted Functions

Enables several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in several processes, including positive regulation of protein localization; positive regulation of signal transduction; and regulation of neuroinflammatory response. Acts upstream of with a positive effect on memory and social behavior. Acts upstream of or within with a positive effect on CXCL12-activated CXCR4 signaling pathway. Acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly; osteoclast differentiation; and positive regulation of macromolecule metabolic process. Located in plasma membrane. Is integral component of membrane and intrinsic component of plasma membrane. Part of plasma membrane raft. Biomarker of syphilis.

Mouse Trem2 Target Information

  • Target Symbol: Trem2, triggering receptor expressed on myeloid cells 2
  • Alias:
    • Trem2a
    • Trem2b
    • Trem2c
    • triggering receptor expressed on myeloid cells 2a
    • triggering receptor expressed on myeloid cells 2b
    • triggering receptor expressed on myeloid cells 2c
  • NCBI_Gene: 83433

Mouse Trem2 Predicted Functions

Enables several functions, including lipopolysaccharide binding activity; lipoteichoic acid binding activity; and peptidoglycan binding activity. Involved in several processes, including regulation of cytokine production; regulation of signal transduction; and response to bacterium. Acts upstream of or within with a positive effect on defense response to Gram-negative bacterium. Acts upstream of or within with a negative effect on pyroptosis. Acts upstream of or within several processes, including negative regulation of NLRP3 inflammasome complex assembly; phagocytosis, engulfment; and social behavior. Located in plasma membrane. Is integral component of plasma membrane. Is expressed in central nervous system; embryo mesenchyme; genitourinary system; and limb interdigital region. Used to study frontotemporal dementia. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2).

Rat Trem2 Target Information

Rat Trem2 Predicted Functions

Predicted to enable several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in cellular response to glucose stimulus and cellular response to hypoxia. Predicted to be located in plasma membrane raft. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2).

TREM2 Target News

    Nervous System Diseases (Depression & Alzheimer & Epilepsy & Parkinson)

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