Human LDL Receptor/LDLR ELISA Kit

$350.00$450.00

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TARGETSLDLR
SPECIESHuman
Sample TypeSerum, plasma, cell culture supernatant, and other biological samples
Sample Volume10 μL
Sensitivity6.32 pg/mL
Range125.00 pg/mL – 8000 pg/mL
Assay Time3.5 h
Recovery101%112%
Average Recovery1.07
Sample TypeSerum, plasma, cell culture supernatant, and other biological samples
Sample Volume10 μL
Sensitivity6.32 pg/mL
Range125.00 pg/mL – 8000 pg/mL
Assay Time3.5 h
Recovery101%112%
Average Recovery1.07
Intra Precision3.0% – 4.3%
Inter-Precision2.3% – 3.6%
PlatformELISA
PlateDetachable 96-well plate
Size96T/48T
StorageIf the reagent kit is unopened, it should be stored at 4℃. However, if it has been opened, the standard solution should be stored at -20℃, while the other components should be stored at 4℃.
Delivery4℃ blue ice transportation
Components96-well polystyrene enzyme-linked immunosorbent assay (ELISA) plate coated with anti-LDLR monoclonal antibody
Human LDLR freeze-dried standard
LDLR detect Antibody
Assay Buffer(10×)
Substrate TMB
Stop Solution
Washing Buffer(20×)
Sealing Film
Assay PrincipleThis kit utilizes the double antibody sandwich enzyme-linked immunosorbent assay (ELISA) detection technique.Specific anti-human LDLR antibodies are precoated on a high-affinity ELISA plate. Standard samples, test samples, and the detection antibody labeled with horseradish peroxidase are added to the wells of the ELISA plate. After incubation, LDLR present in the samples binds to the solid-phase antibodies and the detection antibodies. After washing, a colorimetric substrate, TMB, is added and the plate is incubated in the dark for color development. The intensity of the color reaction is directly proportional to the concentration of LDLR in the samples. A stop solution is added to terminate the reaction, and the absorbance value is measured at a wavelength of 450 nm (with a reference wavelength range of 570-630 nm).

 

Targets

LDLR

LDLR Target Infomation Overview

  • Target Symbol: LDLR, low density lipoprotein receptor
  • Gene Groups: Low density lipoprotein receptors; MicroRNA protein coding host genes
  • Alias: LDLCQ2
  • Alias Names: familial hypercholesterolemia

LDLR, low density lipoprotein receptor Target Infomation by Species

HumanMouseRat

Human LDLR Target Information

  • Target Symbol: LDLR, low density lipoprotein receptor
  • Alias:
    • FH
    • FHC
    • FHCL1
    • LDL receptor
    • LDLCQ2
    • low-density lipoprotein receptor
    • low-density lipoprotein receptor class A domain-containing protein 3
  • NCBI_Gene: 3949
  • UniProtKB: P01130

Human LDLR Predicted Functions

Enables several functions, including low-density lipoprotein particle binding activity; low-density lipoprotein particle receptor activity; and very-low-density lipoprotein particle receptor activity. Involved in several processes, including cholesterol homeostasis; cholesterol transport; and long-term memory. Located in several cellular components, including clathrin-coated pit; endosome; and external side of plasma membrane. Part of PCSK9-LDLR complex and receptor complex. Implicated in Alzheimer’s disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Biomarker of systemic lupus erythematosus.

Mouse Ldlr Target Information

Mouse Ldlr Predicted Functions

Enables several functions, including amyloid-beta binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including lipid transport; regulation of inflammatory response; and regulation of lipid metabolic process. Acts upstream of or within several processes, including cholesterol homeostasis; lipoprotein catabolic process; and low-density lipoprotein particle clearance. Located in several cellular components, including basolateral plasma membrane; endosome; and lysosome. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; paravertebral ganglion; and sensory organ. Used to study familial hypercholesterolemia and fatty liver disease. Human ortholog(s) of this gene implicated in Alzheimer’s disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor).

Rat Ldlr Target Information

Rat Ldlr Predicted Functions

Enables low-density lipoprotein particle receptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of triglyceride catabolic process; and response to glucagon. Located in caveola and recycling endosome membrane. Used to study atherosclerosis and xanthomatosis. Human ortholog(s) of this gene implicated in Alzheimer’s disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor).

LDLR Target News

    Cardiovascular Disease (Hypertension & Atherosclerosis & Acute Myocardial Infarction & Coronary Heart Disease)
    Nervous System Diseases (Depression & Alzheimer & Epilepsy & Parkinson)
    Obesity Diabetes

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