Human Heregulinβ-1 ELISA Kit

$350.00$450.00

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TARGETSNRG1
SPECIESHuman
Sample TypeSerum, plasma, cell culture supernatant, and other biological samples
Sample Volume50 μL
Sensitivity1.54 pg/mL
Range31.25 pg/mL – 2000 pg/mL
Assay Time3.5 h
Recovery83% – 103%
Average Recovery0.86
Sample TypeSerum, plasma, cell culture supernatant, and other biological samples
Sample Volume50 μL
Sensitivity1.54 pg/mL
Range31.25 pg/mL – 2000 pg/mL
Assay Time3.5 h
Recovery83% – 103%
Average Recovery0.86
Intra Precision3.6% – 4.9%
Inter-Precision4.1%-6.8%
PlatformELISA
PlateDetachable 96-well plate
Size96T/48T
StorageIf the reagent kit is unopened, it should be stored at 4℃. However, if it has been opened, the standard solution should be stored at -20℃, while the other components should be stored at 4℃.
Delivery4℃ blue ice transportation
Components96-well polystyrene enzyme-linked immunosorbent assay (ELISA) plate coated with anti-Heregulinβ-1 monoclonal antibody
Human Heregulinβ-1 freeze-dried standard
Human Heregulinβ-1 detect Antibody
Standard Diluent
Assay Buffer(10×)
Substrate TMB
Stop Solution
Washing Buffer(20×)
Sealing Film
Assay PrincipleThis kit utilizes the double antibody sandwich enzyme-linked immunosorbent assay (ELISA) detection technique.Specific anti-human Heregulinβ-1 antibodies are precoated on a high-affinity ELISA plate. Standard samples, test samples, and biotinylated detection antibodies are added to the wells of the ELISA plate. After incubation, Heregulinβ-1 present in the samples binds to the solid-phase antibodies and the detection antibodies. After washing to remove unbound substances, streptavidin-HRP labeled with horseradish peroxidase is added. After washing, a colorimetric substrate, TMB, is added and the plate is incubated in the dark for color development. The intensity of the color reaction is directly proportional to the concentration of Heregulinβ-1 in the samples.A stop solution is added to terminate the reaction, and the absorbance value is measured at a wavelength of 450 nm (with a reference wavelength range of 570-630 nm).

 

Targets

NRG1

NRG1 Target Infomation Overview

  • Target Symbol: NRG1, neuregulin 1
  • Gene Groups: I-set domain containing; Neuregulins
  • Alias: HRG; NDF; GGF
  • Previous Names: HGL; NRG1-IT2
  • Alias Names: NRG1 intronic transcript 2 (non-protein coding)

NRG1, neuregulin 1 Target Infomation by Species

HumanMouseRat

Human NRG1 Target Information

  • Target Symbol: NRG1, neuregulin 1
  • Alias:
    • acetylcholine receptor-inducing activity
    • ARIA
    • GGF
    • GGF2
    • glial growth factor
    • glial growth factor 2
    • heregulin, alpha (45kD, ERBB2 p185-activator)
    • HGL
    • HRG
    • HRG1
    • HRGA
    • MST131
    • MSTP131
    • NDF
    • neu differentiation factor
    • neuregulin 1 type IV beta 1a
    • neuregulin 1 type IV beta 3
    • NRG1 intronic transcript 2 (non-protein coding)
    • NRG1-IT2
    • pro-neuregulin-1, membrane-bound isoform
    • pro-NRG1
    • sensory and motor neuron derived factor
    • SMDF
  • NCBI_Gene: 3084
  • UniProtKB: Q02297

Human NRG1 Predicted Functions

Enables protein tyrosine kinase activator activity; signaling receptor binding activity; and transcription coregulator activity. Involved in several processes, including ERBB signaling pathway; heart development; and positive regulation of protein phosphorylation. Acts upstream of or within cellular protein complex disassembly and negative regulation of transcription, DNA-templated. Located in apical plasma membrane; extracellular space; and nucleoplasm. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Biomarker of Alzheimer’s disease; hepatocellular carcinoma; major depressive disorder; and ovarian cancer.

Mouse Nrg1 Target Information

Mouse Nrg1 Predicted Functions

Enables ErbB-2 class receptor binding activity and chemorepellent activity. Involved in several processes, including positive regulation of cardiac muscle cell differentiation; postsynapse to nucleus signaling pathway; and synapse assembly. Acts upstream of or within several processes, including neurogenesis; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in several cellular components, including axolemma; external side of plasma membrane; and neuromuscular junction. Is integral component of plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1).

Rat Nrg1 Target Information

Rat Nrg1 Predicted Functions

Enables receptor tyrosine kinase binding activity. Involved in several processes, including negative regulation of corticosterone secretion; positive regulation of Schwann cell proliferation; and response to progesterone. Located in extracellular space and synapse. Used to study sciatic neuropathy. Biomarker of diabetic neuropathy; median neuropathy; schizophrenia; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1).

NRG1 分子靶点最新资讯

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