Human IGF-1R/CD221 ELISA Kit

$350.00$450.00

TARGETS IGF1R
SPECIES Human
Sample Type Serum, plasma, cell culture supernatant, and other biological samples
Sample Volume 20 μL
Sensitivity 13.27 pg/mL
Range 0.22 ng/mL – 14 ng/mL
Assay Time 3.5 h
Recovery 73% – 113%
Average Recovery 0.91
Sample Type Serum, plasma, cell culture supernatant, and other biological samples
Sample Volume 20 μL
Sensitivity 13.27 pg/mL
Range 0.22 ng/mL – 14 ng/mL
Assay Time 3.5 h
Recovery 73% – 113%
Average Recovery 0.91
Intra Precision 4.2% – 9.2%
Inter-Precision 5.7%-9.7%
Platform ELISA
Plate Detachable 96-well plate
Size 96T/48T
Storage If the reagent kit is unopened, it should be stored at 4℃. However, if it has been opened, the standard solution should be stored at -20℃, while the other components should be stored at 4℃.
Delivery 4℃ blue ice transportation
Components 96-well polystyrene enzyme-linked immunosorbent assay (ELISA) plate coated with anti-IGF-1R/CD221 monoclonal antibody
Human IGF-1R/CD221 freeze-dried standard
IGF-1R/CD221 detect Antibody
Standard Diluent
HRP-labeled streptavidin
Signal enhancer concentrate
Signal enhancer diluent
Assay Buffer(10×)
Substrate TMB
Stop Solution
Washing Buffer(20×)
Sealing Film
Assay Principle This kit utilizes the double antibody sandwich enzyme-linked immunosorbent assay (ELISA) detection technique.Specific anti-human IGF-1R antibodies are precoated on a high-affinity ELISA plate. Standard samples, test samples, and biotinylated detection antibodies are added to the wells of the ELISA plate. After incubation, IGF-1R present in the samples binds to the solid-phase antibodies and the detection antibodies. After washing to remove unbound substances, streptavidin-HRP labeled with horseradish peroxidase is added. After washing, a colorimetric substrate, TMB, is added and the plate is incubated in the dark for color development. The intensity of the color reaction is directly proportional to the concentration of IGF-1R in the samples.A stop solution is added to terminate the reaction, and the absorbance value is measured at a wavelength of 450 nm (with a reference wavelength range of 570-630 nm).

 

Targets

IGF1R

IGF1R Target Infomation Overview

  • Target Symbol: IGF1R, insulin like growth factor 1 receptor
  • Gene Groups: Receptor tyrosine kinases; CD molecules; Fibronectin type III domain containing; MicroRNA protein coding host genes
  • Alias: JTK13; CD221; IGFIR; MGC18216; IGFR
  • Alias Names: insulin-like growth factor 1 receptor

IGF1R, insulin like growth factor 1 receptor Target Infomation by Species

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Human IGF1R Target Information

  • Target Symbol: IGF1R, insulin like growth factor 1 receptor
  • Alias:
    • CD221
    • IGF-I receptor
    • IGFIR
    • IGFR
    • insulin-like growth factor 1 receptor
    • insulin-like growth factor I receptor
    • JTK13
    • MGC142170
    • MGC142172
    • MGC18216
    • soluble IGF1R variant 1
    • soluble IGF1R variant 2
  • NCBI_Gene: 3480
  • UniProtKB: P08069

Human IGF1R Predicted Functions

Enables several functions, including insulin binding activity; insulin receptor binding activity; and insulin receptor substrate binding activity. Involved in several processes, including cellular response to amyloid-beta; insulin-like growth factor receptor signaling pathway; and regulation of MAPK cascade. Acts upstream of or within peptidyl-tyrosine autophosphorylation. Located in intracellular membrane-bounded organelle and membrane. Part of alphav-beta3 integrin-IGF-1-IGF1R complex; protein kinase complex; and receptor complex. Implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and nervous system cancer (multiple). Biomarker of several diseases, including Kuhnt-Junius degeneration; autoimmune disease (multiple); endocrine gland cancer (multiple); neurodegenerative disease (multiple); and prostate disease (multiple).

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Mouse Igf1r Target Information

Mouse Igf1r Predicted Functions

Enables insulin-like growth factor binding activity. Involved in several processes, including adrenal gland development; positive regulation of cold-induced thermogenesis; and positive regulation of meiotic cell cycle. Acts upstream of or within several processes, including gland development; peptidyl-tyrosine autophosphorylation; and regulation of intracellular signal transduction. Located in T-tubule. Is integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and lung. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).

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Rat Igf1r Target Information

Rat Igf1r Predicted Functions

Enables G-protein alpha-subunit binding activity; insulin receptor substrate binding activity; and insulin-like growth factor-activated receptor activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and nervous system development. Located in several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer’s disease; Parkinson’s disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); cryptorchidism; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and nervous system cancer (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).

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IGF1R Target News

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