Human TrkB/NTRK2 ELISA Kit

$350.00$450.00

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TARGETSNTRK2
SPECIESHuman
Sample TypeSerum, plasma, cell culture supernatant, and other biological samples
Sample Volume100 μL
Sensitivity0.80 pg/mL
Range15.63 pg/mL – 1000 pg/mL
Assay Time3.5 h
Recovery88% – 112%
Average Recovery0.97
Sample TypeSerum, plasma, cell culture supernatant, and other biological samples
Sample Volume100 μL
Sensitivity0.80 pg/mL
Range15.63 pg/mL – 1000 pg/mL
Assay Time3.5 h
Recovery88% – 112%
Average Recovery0.97
Intra Precision1.9% – 3.0%
Inter-Precision3.3% – 3.6%
PlatformELISA
PlateDetachable 96-well plate
Size96T/48T
StorageIf the reagent kit is unopened, it should be stored at 4℃. However, if it has been opened, the standard solution should be stored at -20℃, while the other components should be stored at 4℃.
Delivery4℃ blue ice transportation
Components96-well polystyrene enzyme-linked immunosorbent assay (ELISA) plate coated with anti-TrkB/NTRK2 monoclonal antibody
Human TrkB/NTRK2 freeze-dried standard
Human TrkB/NTRK2 detect Antibody
Standard Diluent
Assay Buffer(10×)
Substrate TMB
Stop Solution
Washing Buffer(20×)
Sealing Film
Assay PrincipleThis kit utilizes the double antibody sandwich enzyme-linked immunosorbent assay (ELISA) detection technique.Specific anti-human TrkB antibodies are precoated on a high-affinity ELISA plate. Standard samples, test samples, and the detection antibody labeled with horseradish peroxidase are added to the wells of the ELISA plate. After incubation, TrkB present in the samples binds to the solid-phase antibodies and the detection antibodies. After washing, a colorimetric substrate, TMB, is added and the plate is incubated in the dark for color development. The intensity of the color reaction is directly proportional to the concentration of TrkB in the samples. A stop solution is added to terminate the reaction, and the absorbance value is measured at a wavelength of 450 nm (with a reference wavelength range of 570-630 nm).

 

Targets

NTRK2

NTRK2 Target Infomation Overview

  • Target Symbol: NTRK2, neurotrophic receptor tyrosine kinase 2
  • Gene Groups: Receptor tyrosine kinases; I-set domain containing
  • Alias: TRKB
  • Alias Names: BDNF/NT-3 growth factors receptor; neurotrophic tyrosine kinase, receptor, type 2

NTRK2, neurotrophic receptor tyrosine kinase 2 Target Infomation by Species

HumanMouseRat

Human NTRK2 Target Information

  • Target Symbol: NTRK2, neurotrophic receptor tyrosine kinase 2
  • Alias:
    • BDNF-tropomyosine receptor kinase B
    • BDNF/NT-3 growth factors receptor
    • DEE58
    • EIEE58
    • GP145-TrkB
    • neurotrophic tyrosine kinase receptor type 2
    • neurotrophic tyrosine kinase, receptor, type 2
    • neurotrophic tyrosine receptor kinase type 2
    • OBHD
    • trk-B
    • TRKB
    • trkB tyrosine kinase
    • tropomyosin-related kinase B
    • tyrosine kinase receptor B
  • NCBI_Gene: 4915
  • UniProtKB: Q16620

Human NTRK2 Predicted Functions

Enables brain-derived neurotrophic factor-activated receptor activity; neurotrophin binding activity; and protease binding activity. Involved in brain-derived neurotrophic factor receptor signaling pathway. Acts upstream of or within negative regulation of amyloid-beta formation. Is integral component of plasma membrane. Part of receptor complex. Implicated in Alzheimer’s disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Biomarker of bipolar disorder; idiopathic pulmonary fibrosis; major depressive disorder; and schizophrenia.

Mouse Ntrk2 Target Information

Mouse Ntrk2 Predicted Functions

Enables brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor-activated receptor activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; nervous system development; and trans-synaptic signaling, modulating synaptic transmission. Acts upstream of or within several processes, including neurogenesis; neuronal action potential propagation; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including early endosome; postsynaptic density; and postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; future brain; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer’s disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).

Rat Ntrk2 Target Information

  • Target Symbol: Ntrk2, neurotrophic receptor tyrosine kinase 2
  • Alias:
    • BDNF/NT-3 growth factors receptor
    • GP145-TrkB/GP95-TrkB
    • Neural receptor protein-tyrosine kinase (trkB)
    • neurotrophic tyrosine kinase, receptor, type 2
    • neurotrophic tyrosine receptor kinase type 2
    • RATTRKB1
    • Tkrb
    • trk-B
    • trkB
    • trkB tyrosine kinase
    • TRKB1
  • NCBI_Gene: 25054

Rat Ntrk2 Predicted Functions

Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor-activated receptor activity; and protein homodimerization activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; positive regulation of cell communication; and regulation of neuron projection development. Acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway. Located in several cellular components, including distal axon; perikaryon; and postsynaptic density. Is integral component of plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study glaucoma. Biomarker of several diseases, including attention deficit hyperactivity disorder; colitis; mental depression; post-traumatic stress disorder; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer’s disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).

NTRK2 Target News

    Eye Diseases (Glaucoma & Cataract)
    Nervous System Diseases (Depression & Alzheimer & Epilepsy & Parkinson)

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