Mouse IL-18 ELISA Kit

$350.00$450.00

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TARGETSIL18
SPECIESMouse
Sample TypeSerum, plasma, cell culture supernatant, and other biological samples
Sample VolumeSerum, plasma: 20 μL;cell culture supernatant: 100 μL
Sensitivity0.93 pg/mL
Range62.5 pg/mL – 4000 pg/mL
Assay Time3.5 h
Recovery80% – 119%
Average Recovery0.98
Sample TypeSerum, plasma, cell culture supernatant, and other biological samples
Sample VolumeSerum, plasma: 20 μL;cell culture supernatant: 100 μL
Sensitivity0.93 pg/mL
Range62.5 pg/mL – 4000 pg/mL
Assay Time3.5 h
Recovery80% – 119%
Average Recovery0.98
Intra Precision2.7% – 4.0%
Inter-Precision2.4% – 3.7%
PlatformELISA
PlateDetachable 96-well plate
Size96T/48T
StorageIf the reagent kit is unopened, it should be stored at 4℃. However, if it has been opened, the standard solution should be stored at -20℃, while the other components should be stored at 4℃.
Delivery4℃ blue ice transportation
Components96-well polystyrene enzyme-linked immunosorbent assay (ELISA) plate coated with anti-Mouse IL-18 monoclonal antibody
Mouse IL-18 freeze-dried standard
IL-18 detect Antibody
HRP-labeled streptavidin
Assay Buffer(10×)
Substrate TMB
Stop Solution
Washing Buffer(20×)
Sealing Film
Assay PrincipleThis kit utilizes the double antibody sandwich enzyme-linked immunosorbent assay (ELISA) detection technique.Specific anti-mouse IL-18 antibodies are precoated on a high-affinity ELISA plate. Standard samples, test samples, and the detection antibody labeled with horseradish peroxidase are added to the wells of the ELISA plate. After incubation, IL-18 present in the samples binds to the solid-phase antibody and the detection antibody. After washing, a colorimetric substrate, TMB, is added and the plate is incubated in the dark for color development. The intensity of the color reaction is directly proportional to the concentration of IL-18 in the samples.A stop solution is added to terminate the reaction, and the absorbance value is measured at a wavelength of 450 nm (with a reference wavelength range of 570-630 nm).

 


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Targets

IL18

IL18 Target Infomation Overview

  • Target Symbol: IL18, interleukin 18
  • Gene Groups: Interleukins
  • Alias: IGIF; IL1F4; IL-1g; IL-18
  • Alias Names: interferon-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor)

IL18, interleukin 18 Target Infomation by Species

HumanMouseRat

Human IL18 Target Information

  • Target Symbol: IL18, interleukin 18
  • Alias:
    • iboctadekin
    • IFN-gamma-inducing factor
    • IGIF
    • IL-1 gamma
    • IL-18
    • IL-1g
    • IL1F4
    • interferon gamma-inducing factor
    • interleukin 18 (interferon-gamma-inducing factor)
    • interleukin-1 gamma
    • interleukin-18
    • MGC12320
  • NCBI_Gene: 3606
  • UniProtKB: Q14116

Human IL18 Predicted Functions

Enables cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in extracellular space. Implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Biomarker of several diseases, including autoimmune disease (multiple); cholestasis (multiple); liver disease (multiple); lung disease (multiple); and myositis (multiple).

Mouse Il18 Target Information

Mouse Il18 Predicted Functions

Enables cytokine activity. Involved in lipid homeostasis; positive regulation of cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interferon-gamma production. Located in extracellular space. Is expressed in several structures, including back skin; dorsal aorta; gut; lymphatic system; and reproductive system. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18).

Rat Il18 Target Information

Rat Il18 Predicted Functions

Predicted to enable cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of cell population proliferation; and positive regulation of cytokine production. Located in apical plasma membrane; cytoplasm; and extracellular space. Used to study brain edema; fatty liver disease; heart disease; status epilepticus; and vasculitis. Biomarker of several diseases, including cardiac arrest; ischemia (multiple); lung disease (multiple); perinatal necrotizing enterocolitis; and urinary tract infection. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18).

IL18 Target News

2.6
Huoxue Jiedu Recipe represses mitochondrial fission to alleviate submandibular gland inflammation in Sjögren’s syndrome
MICROBIOLOGY AND IMMUNOLOGY
3.7
Involvement of estrogen receptor activation in kaempferol-3-O-glucoside’s protection against aging-related cognition impairment and microglial inflammation
EXPERIMENTAL CELL RESEARCH
6.2
Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson’s disease: targeting neuroinflammation
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
5.314
Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
5.4
Involvement of the JNK/HO‑1/FTH1 signaling pathway in nanoplastic‑induced inflammation and ferroptosis of BV2 microglia cells
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
7.3
Salvianolic acid B ameliorates neuroinflammation and neuronal injury via blocking NLRP3 inflammasome and promoting SIRT1 in experimental subarachnoid hemorrhage
Frontiers in Immunology
4.5
Electroacupuncture Alleviates Lung Injury in CpG1826-Challenged Mice via Modulating CD39-NLRP3 Pathway
Journal of Inflammation Research
5.2
Ginkgolide attenuates memory impairment and neuroinflammation by suppressing the NLRP3/caspase-1 pathway in Alzheimer’s disease
Aging-US
2.264
Tilianin Protects against Nonalcoholic Fatty Liver Disease in Early Obesity Mice
BIOLOGICAL & PHARMACEUTICAL BULLETIN
4.4
The protective role of chicken cathelicidin-1 against Streptococcus suis serotype 2 in vitro and in vivo
VETERINARY RESEARCH
4.9
Schisandrin protects against ulcerative colitis by inhibiting the SGK1/NLRP3 signaling pathway and reshaping gut microbiota in mice
Chinese Medicine
4.9
Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice
Chinese Medicine
4.925
Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal Epithelium Defects in an Experimental Dry Eye Model
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
2.65
Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Bilobalide
Evidence-based Complementary and Alternative Medicine
8.755
Tetrahedral framework nucleic acid nanomaterials reduce the inflammatory damage in sepsis by inhibiting pyroptosis
CELL PROLIFERATION
5.7
Peptide MSI-1 inhibited MCR-1 and regulated outer membrane vesicles to combat immune evasion of Escherichia coli
Microbial Biotechnology
Allergic Reaction
Cardiovascular Disease (Hypertension & Atherosclerosis & Acute Myocardial Infarction & Coronary Heart Disease)
Lung Disease (Asthma & COPD)
Multiple Sclerosis
Nervous System Diseases (Depression & Alzheimer & Epilepsy & Parkinson)
Obesity Diabetes
Osteoarthrosis & Rheumatoid Arthritis
Sepsis
Systemic Lupus Erythematosus
Transplantation

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